{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:50:54Z","timestamp":1789008654245,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the natural history and impact of irritable bowel syndrome (IBS)\u2010type symptoms on psychological health and quality of life in inflammatory bowel disease (IBD). We aimed to address this in a 12\u2010month longitudinal follow\u2010up study of secondary care patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected demographic, Rome III IBS\u2010type symptom, psychological, and quality of life data, with questionnaires at 3\u2010month intervals, over 12\u2009months of follow\u2010up in patients with IBD in clinical remission at baseline. We assessed the natural history of Rome III IBS\u2010type symptoms over the 12\u2009months of the study and compared psychological and quality of life data between those reporting Rome III IBS\u2010type symptoms at each of the points of follow\u2010up with those not reporting such symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Among 206 patients with IBD in clinical remission at baseline (104 [50.5%] women, mean age 56.9\u2009years [range 18\u201383\u2009years], 79 [38.3%] Crohn's disease), 33 (16.0%) reported Rome III IBS\u2010type symptoms at baseline and 72 (35.0%) reported Rome III IBS\u2010type symptoms at one or more time points. Among the 33 patients with Rome III IBS\u2010type symptoms at baseline, symptoms resolved in 6 (18.2%) patients, were present throughout in 6 (18.2%) patients, and fluctuated in the remaining 21 (63.6%) patients. Among the 39 patients with new onset of Rome III IBS\u2010type symptoms after baseline, 24 (65.1%) had symptoms at one point in time only, 10 (25.6%) at two points, four (10.3%) at three points, and one (2.6%) at four points. At each point in time, reporting IBS\u2010type symptoms was associated with significantly higher anxiety, depression, or somatoform symptom\u2010reporting scores, and\/or lower quality of life scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In this 12\u2010month follow\u2010up study, one\u2010third of patients with IBD reported presence of Rome III IBS\u2010type symptoms at any point in time. Reporting such symptoms was associated with significant impacts on psychological health and\/or quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14713","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T23:50:38Z","timestamp":1700869838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Natural history and impact of irritable bowel syndrome\u2010type symptoms in inflammatory bowel disease during 12\u2009months of longitudinal follow\u2010up"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-8243","authenticated-orcid":false,"given":"Brigida","family":"Barberio","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, Gastroenterology Unit University Hospital of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-4762","authenticated-orcid":false,"given":"Keeley M.","family":"Fairbrass","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"},{"name":"Leeds Institute of Medical Research St. James's, University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Gracie","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"},{"name":"Leeds Institute of Medical Research St. James's, University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4359","authenticated-orcid":false,"given":"Alexander C.","family":"Ford","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"},{"name":"Leeds Institute of Medical Research St. James's, University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318936"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000955"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-11-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.053"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30300-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx152"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X17744739"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12163"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17193"},{"key":"e_1_2_11_14_1","first-page":"835","volume-title":"Rome III: The Functional Gastrointestinal Disorders","author":"Whitehead WE","year":"2006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92767-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/tmj.2018.0264"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.1.29"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.01.001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000654"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04402.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200203000-00008"},{"key":"e_1_2_11_24_1","first-page":"1571","article-title":"The short inflammatory bowel disease questionnaire: a quality of life instrument for community physicians managing inflammatory bowel disease. 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