{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:22:56Z","timestamp":1774635776398,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colonic motility is regulated by various factors along the gut\u2010brain axis; however, detailed mechanisms are unknown. This study aimed to examine the involvement of the autonomic nervous system in colonic motility. <jats:italic>Suncus murinus<\/jats:italic> (suncus) is a small laboratory mammal suitable for gastrointestinal motility studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Colonic motility and concomitant feeding and defecation behaviors in vagotomized and reserpine\u2010administered suncus were recorded simultaneously for 24\u2009h. Furthermore, we performed immunohistochemistry on tyrosine hydroxylase (TH) and in\u00a0situ hybridization on corticotropin\u2010releasing hormone (CRH) in suncus brain. Additionally, we examined c\u2010Fos expression in the brain using immunohistochemistry in conscious suncus with colorectal distension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In vagotomized suncus, clustered giant migrating contractions (GMCs), consisting of strong contractions occurring in a short time, were observed, and the percentage of GMCs without defecation increased. The frequency of GMCs in the reserpine\u2010administered suncus increased during a light period (ZT0\u20104, 4\u20138) and decreased during a dark period (ZT16\u201020, 20\u201324) compared to a vehicle group. Additionally, the percentage of GMCs without defecation in the reserpine\u2010administered suncus increased. Suncus TH\u2010immunopositive neurons were found in the locus coeruleus (LC), as shown in rodents. In contrast, CRH mRNA\u2010expressing cells were not observed in a region assumed to be the Barrington's nucleus (Bar). Furthermore, colorectal distension in conscious suncus induced c\u2010Fos expression in LC TH neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Our results suggest that the vagus and sympathetic nerves are not required for induction of GMCs in\u00a0vivo. However, they are likely to exert a modulatory role in control of GMC frequency in <jats:italic>Suncus murinus<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14716","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T05:49:18Z","timestamp":1701323358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Involvement of the autonomic nervous system in colonic contractions in conscious <i>Suncus murinus<\/i>"],"prefix":"10.1111","volume":"36","author":[{"given":"Miu","family":"Suzuki","sequence":"first","affiliation":[{"name":"Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering Saitama University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering Saitama University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[{"name":"Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering Saitama University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering Saitama University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-0407","authenticated-orcid":false,"given":"Ichiro","family":"Sakata","sequence":"additional","affiliation":[{"name":"Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering Saitama University  Saitama Japan"},{"name":"Area of Research Evolutionary Molecular Design, Strategic Research Center Saitama University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301759"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.3.397"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90966-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00317.2020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14302"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00114.2001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00278.2010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011116107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.02.063"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3846-13.2013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90913-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00293.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0799-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(74)80114-9"},{"key":"e_1_2_10_17_1","first-page":"1","article-title":"Extrinsic nervous control of colonic motility and blood flow. 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