{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:55Z","timestamp":1753878655590,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK097112"],"award-info":[{"award-number":["R01 DK097112"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Standard impedance catheters and balloon\u2010based mucosal impedance catheters (BBMI) have been used to assess mucosal integrity and diagnose mucosal diseases. The goal of this study was to determine the age\u2010related technical issues associated with mucosal balloon inflation, validate the BBMI measurement against a standard impedance probe, and compare software\u2010generated diagnoses to histologic diagnoses.<\/jats:p><\/jats:sec>Methods<\/jats:title>We prospectively recruited patients undergoing endoscopy, during which patients underwent standard mucosal impedance catheters and BBMI measurements. Measurements were compared to each other, to the histologic diagnoses, and to the number of eosinophils per high power field. We then compared the patients' diagnosis to that assigned by the BBMI software.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Sixty\u2010two patients (mean age: 62\u2009\u00b1\u200962\u2009months) were recruited, including non\u2010GERD (N<\/jats:italic>\u2009=\u200940), GERD (N<\/jats:italic>\u2009=\u200915), and EoE (N<\/jats:italic>\u2009=\u20097) patients. There were significant differences between the impedance values measured by the two technologies at each esophageal height (p<\/jats:italic>\u2009<\u20090.003). There were significant correlations between the mean impedance values taken by the two catheters in the distal (r<\/jats:italic>2<\/jats:sup>\u2009=\u20090.272, p<\/jats:italic>\u2009=\u20090.04), mid (r<\/jats:italic>2<\/jats:sup>\u2009=\u20090.371, p<\/jats:italic>\u2009<\u20090.001), and proximal (r<\/jats:italic>2<\/jats:sup>\u2009=\u20090.259, p<\/jats:italic>\u2009=\u20090.05) esophagus. There were significant differences in BBMI impedance values across diagnoses in the mid and proximal esophagus (p<\/jats:italic>\u2009=\u20090.024 and 0.025, respectively). While not statistically significant (p<\/jats:italic>\u2009=\u20090.061\u20130.073), the standard catheter showed similar trends by diagnosis. Using the BBMI diagnostic prediction software, 33%\u201372% of patients were misclassified.<\/jats:p><\/jats:sec>Conclusion and Inferences<\/jats:title>While there was significant variability in impedance values between technologies within patients, regional measurements were consistent across catheters. Automated analyses lacked the sensitivity to diagnose inflammatory disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14726","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:13:33Z","timestamp":1703218413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The utility of balloon\u2010based and standard impedance technology to diagnose esophageal mucosal diseases in children"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-3060","authenticated-orcid":false,"given":"Rachel","family":"Rosen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Aerodigestive Center Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maritha","family":"Du","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Aerodigestive Center Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Akkara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Aerodigestive Center Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Catacora","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Aerodigestive Center Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Aerodigestive Center Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enju","family":"Liu","sequence":"additional","affiliation":[{"name":"Institutional Centers for Clinical and Translational Research Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0936-4807","authenticated-orcid":false,"given":"Samuel","family":"Nurko","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Aerodigestive Center Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.08.031"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001943"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-018-0639-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.12.020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.253"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20073"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517987"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003396"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T02:35:37Z","timestamp":1708050937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/nmo.14726"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14726","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2023,12,21]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14726"}}