{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:11:26Z","timestamp":1787595086362,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse childhood experiences (ACEs) are linked to the development of gastrointestinal disorders during adulthood, but there is limited research on the prevalence of ACEs in Latin American populations. This study aimed to assess the prevalence and impact of ACEs on Mexican adults with irritable bowel syndrome (IBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, we recruited 290 Mexican adults (aged 18\u201365), including 90 individuals with IBS and 200 healthy controls. All participants completed four self\u2010reported questionnaires: The Adverse Childhood Experiences Questionnaire (ACEs), Visceral Sensitivity Index, Irritable Bowel Syndrome Symptom Severity Scale, and Hospital Anxiety and Depression Scale. Statistical analyses included mean differences using either the Student's <jats:italic>t<\/jats:italic>\u2010test or the Wilcoxon test, correlations assessed with Spearman's correlation coefficient, and logistic regression models. Statistical significance was defined as a <jats:italic>p<\/jats:italic>\u2010value less than 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Among IBS subjects, the prevalence of ACEs was 80%, significantly higher than the 59% prevalence observed in controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Individuals with ACEs exhibited elevated levels of anxiety and depression. Seventy\u2010five percent of IBS subjects with severe symptoms reported four or more ACEs. The presence of four or more ACEs was found to be associated with an increased risk of IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>ACEs are notably prevalent among Mexican individuals with IBS and are positively correlated with the severity of gastrointestinal pain. These findings underscore the critical significance of evaluating and addressing ACEs in the comprehensive management of IBS within Latin American populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14743","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:15:55Z","timestamp":1705727755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association of adverse childhood experiences with irritable bowel syndrome in Mexican adults: A cross\u2010sectional study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-806X","authenticated-orcid":false,"given":"Bryan Adrian","family":"Priego\u2010Parra","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Motilidad Digestiva, Instituto de Investigaciones M\u00e9dico\u2010Biol\u00f3gicas Universidad Veracruzana  Veracruz Mexico"},{"name":"Centro de Investigaciones 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