{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:39:55Z","timestamp":1792197595497,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory bowel diseases (IBD) are chronic diseases that are not fully understood. Drugs in use can only be applied for a short time due to their side effects. Therefore, research is needed to develop new treatment approaches. In addition, it has been proven that IBD causes degeneration in the enteric nervous system (ENS). In recent years, it has been discussed that probiotics may have positive effects in the prevention and treatment of inflammatory enteric degeneration. <jats:italic>Akkermansia muciniphila<\/jats:italic> (<jats:italic>A. muciniphila<\/jats:italic>) is an anaerobic bacterium found in the mucin layer of the intestinal microbiota. It has been found that the population of <jats:italic>A. muciniphila<\/jats:italic> decreases in the case of different diseases. In light of this information, the curative effect of <jats:italic>A. muciniphila<\/jats:italic> application on colitis\u2010induced inflammation and enteric degeneration was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 5\u2009weeks of <jats:italic>A. muciniphila<\/jats:italic> treatment in Trinitro\u2010benzene\u2010sulfonic acid (TNBS)\u2013induced chronic colitis model was investigated. Colon samples were examined at microscopic, biochemical, and molecular levels. Fecal samples were collected before, during, and after treatment to evaluate the population changes in the microbiota. Specific proteins secreted from the ENS were evaluated, and enteric degeneration was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As a result of the research, the ameliorative effects of <jats:italic>A. muciniphila<\/jats:italic> were shown in the TNBS colitis model\u2010induced inflammation and ENS damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In light of these results, <jats:italic>A. muciniphila<\/jats:italic> can potentially be evaluated as a microbiome\u2010based treatment for IBD with further clinical and experimental studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14745","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T07:26:12Z","timestamp":1706081172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Akkermansia muciniphila<\/i> improves chronic colitis\u2010induced enteric 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