{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:46:58Z","timestamp":1768906018570,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020306","name":"Steigerwald Arzneimittelwerk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The herbal preparation, STW5\u2010II, improves upper gastrointestinal symptoms, including abdominal fullness, early satiation, and epigastric pain, in patients with functional dyspepsia, and in preclinical models decreases fundic tone and increases antral contractility. The effects of STW5\u2010II on esophago\u2010gastric junction pressure, proximal gastric tone and antropyloroduodenal pressures, disturbances of which may contribute to symptoms associated with disorders of gut\u2013brain interaction, including functional dyspepsia, in humans, have, hitherto, not been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>STW5\u2010II or placebo (matched for color, aroma, and alcohol content) were each administered orally, at the recommended dose (20 drops), to healthy male and female volunteers (age: 27\u2009\u00b1\u20091\u2009years) in a double\u2010blind, randomized fashion, on two separate occasions, separated by 3\u20137\u2009days, to evaluate effects on (i) esophago\u2010gastric junction pressures following a standardized meal using solid\u2010state high\u2010resolution manometry (part 1, <jats:italic>n<\/jats:italic>\u2009=\u200916), (ii) proximal gastric volume using a barostat (part 2, <jats:italic>n<\/jats:italic>\u2009=\u200916), and (iii) antropyloroduodenal pressures assessed by high\u2010resolution manometry (part 3, <jats:italic>n<\/jats:italic>\u2009=\u200918), for 120\u2009min (part 1) or 180\u2009min (parts 2, 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>STW5\u2010II increased maximum intrabag volume (ml; STW5\u2010II: 340\u2009\u00b1\u200938, placebo: 251\u2009\u00b1\u200930; <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and intrabag volume between <jats:italic>t<\/jats:italic>\u2009=\u2009120 and 180\u2009min (<jats:italic>p<\/jats:italic>\u2009=\u20090.011), and the motility index of antral pressure waves between <jats:italic>t<\/jats:italic>\u2009=\u200960 and 120\u2009min (<jats:italic>p<\/jats:italic>\u2009=\u20090.032), but had no effect on esophago\u2010gastric junction, pyloric, or duodenal pressures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>STW5\u2010II has marked region\u2010specific effects on gastric motility in humans, which may contribute to its therapeutic efficacy in functional dyspepsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14755","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T05:31:59Z","timestamp":1706851919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The herbal preparation, STW5\u2010II, reduces proximal gastric tone and stimulates antral pressures in healthy humans"],"prefix":"10.1111","volume":"36","author":[{"given":"Penelope C. 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