{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:38:34Z","timestamp":1787593114445,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012276","name":"Tillotts Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the characteristics of individuals with irritable bowel syndrome (IBS) according to stool subtype or the most troublesome symptom reported by the individual, or whether these are useful in predicting the impact of IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<jats:bold>s<\/jats:bold><\/jats:title><jats:p>We collected demographic, gastrointestinal, and psychological symptoms, healthcare usage and direct healthcare costs, impact on work and activities of daily living, and quality of life data from individuals with Rome IV\u2010defined IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>We recruited 752 people with Rome IV IBS. Individuals with IBS\u2010D reported a poorer disease\u2010specific quality of life than those with IBS\u2010C or IBS\u2010M (mean (SD) IBS\u2010QOL 45.3 (23.0) for IBS\u2010D, vs. 52.3 (19.9) for IBS\u2010C, vs. 49.4 (22.0) for IBS\u2010M, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). Mean (SD) IBS\u2010QOL scores were also lower amongst those who reported diarrhea (44.8 (22.3)) or urgency (44.6 (22.3)) as their most troublesome symptom, compared with those reporting abdominal pain (52.2 (22.9)), constipation (49.5 (21.8)), or abdominal bloating or distension (50.4 (21.3)). However, there were no differences in mean EQ\u20105D scores, IBS severity, levels of anxiety, depression, somatoform symptom\u2010reporting, or gastrointestinal symptom\u2010specific anxiety. Direct healthcare costs of IBS were similar across all subtypes and all most troublesome symptom groups, although some differences in work productivity and social leisure activities were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>There appears to be limited variation in the characteristics of individuals with Rome IV IBS based on both stool subtypes and most troublesome symptom reported, suggesting that gastrointestinal symptoms alone have limited ability to predict disease impact and burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14756","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:41:05Z","timestamp":1707295265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Utility of irritable bowel syndrome subtypes and most troublesome symptom in predicting disease impact and burden"],"prefix":"10.1111","volume":"36","author":[{"given":"Mais","family":"Khasawneh","sequence":"first","affiliation":[{"name":"Leeds Institute of Medical Research at St. James's University of Leeds  Leeds UK"},{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad Ali","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho Ee","family":"Ng","sequence":"additional","affiliation":[{"name":"County Durham and Darlington NHS Foundation Trust  Durham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5449-3603","authenticated-orcid":false,"given":"Christopher J.","family":"Black","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research at St. James's University of Leeds  Leeds UK"},{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek C.","family":"Goodoory","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research at St. James's University of Leeds  Leeds UK"},{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Ford","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research at St. James's University of Leeds  Leeds UK"},{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31548-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30217-X"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2019.101634"},{"key":"e_1_2_12_7_1","first-page":"159","article-title":"Identification of sub\u2010groups of functional gastrointestinal disorders","volume":"3","author":"Drossman DA TW","year":"1990","journal-title":"Gastroenterol Int"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04948.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000946"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10880-009-9182-7"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2018.09.006"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12704"},{"issue":"2","key":"e_1_2_12_14_1","first-page":"59","article-title":"Irritable bowel syndrome subtypes: clinical and psychological features, body mass index and comorbidities","volume":"108","author":"Kibune Nagasako C","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01440.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.08.016"},{"key":"e_1_2_12_17_1","unstructured":"County Durham and Darlington NHS Foundation Trust.ContactME\u2010IBS [Internet]: County Durham and Darlington NHS Foundation Trust.2021[cited 2023 June 8]. 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