{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:20:39Z","timestamp":1783704039920,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic constipation (CC) is defined by symptom criteria reflecting heterogenous physiology. However, many patients with CC have significant psychological comorbidities\u2014an alternative definition using a biopsychosocial classification model could be warranted to inform future treatments. We sought to: (1) empirically derive psychological symptom profiles of patients with CC using latent profile analysis and (2) validate these profiles by comparing them on symptom severity, GI\u2010specific anxiety, body mass index (BMI), and anorectal manometry findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included adults presenting for anorectal manometry for CC (<jats:italic>N<\/jats:italic>\u2009=\u2009468, 82% female, <jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u2009=\u200947). Depression\/anxiety symptoms and eating disorder (ED) symptoms (EAT\u201026) were used as indicators (i.e., variables used to derive profiles) representing unique psychological constructs. Constipation symptoms, GI\u2010specific anxiety, BMI, and anorectal manometry results were used as validators (i.e., variables used to examine the clinical utility of the resulting profiles).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A 5\u2010profile solution provided the best statistical fit, comprising the following latent profiles (LPs): LP1 termed \u201chigh dieting, low bulimia;\u201d LP2 termed \u201chigh ED symptoms;\u201d LP3 termed \u201cmoderate ED symptoms;\u201d LP4 termed \u201chigh anxiety and depression, low ED symptoms;\u201d and LP5 termed \u201clow psychological symptoms.\u201d The low psychological symptom profile (61% of the sample) had lower abdominal and overall constipation severity and lower GI\u2010specific anxiety compared to the four profiles characterized by higher psychological symptoms (of any type). Profiles did not significantly differ on BMI or anorectal manometry results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Profiles with high psychological symptoms had increased constipation symptom severity and GI\u2010specific anxiety in adults with CC. Future research should test whether these profiles predict differential treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14773","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T05:29:20Z","timestamp":1708752560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3057-6812","authenticated-orcid":false,"given":"Sophie R.","family":"Abber","sequence":"first","affiliation":[{"name":"Department of Psychology Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Clukey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Joiner","sequence":"additional","affiliation":[{"name":"Department of Psychology Florida State University  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-4290","authenticated-orcid":false,"given":"Kyle","family":"Staller","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts 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