{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:44:42Z","timestamp":1787319882580,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic cough significantly impairs the quality of life. Although various studies focused on MNBI as assessed in the distal esophagus, scarce data are available on the clinical value of proximal measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the role of proximal MNBI in the workup of patients with chronic cough and its ability to predict PPI response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographic, clinical, endoscopy findings, impedance\u2010pH and HRM tracings from consecutive cough patients were evaluated. MNBI was calculated at proximal and distal esophagus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and sixty four patients were included. In addition to traditional variables, when considering also the PSPW index or MNBI at 3\u2009cm or 15\u2009cm, the proportion of patients with pathological impedance\u2010pH monitoring significantly increased. 70\/164 patients were responders, while 94 (57.3%) were non\u2010responder to double PPI dose (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Patients with pathologic MNBI at 3\u2009cm and\/or 15\u2009cm as well as those with pathologic PSPW index were characterized by a significantly higher proportion of responders than that observed among patients with normal impedance\u2010pH variables (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The proportion of responders with pathological MNBI at 15\u2009cm was significantly higher than the proportion of responders with pathological MNBI at 3\u2009cm (82.8% vs. 64.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). At multivariable model, pathological MNBI at both 3\u2009cm and 15\u2009cm as well as PSPW index were associated with PPI responsiveness. The strongest association with PPI response was observed for MNBI at 15\u2009cm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The assessment of MNBI at proximal esophagus increases the diagnostic yield of impedance\u2010pH monitoring and may represent a useful predictor of PPI responsiveness in the cumbersome clinical setting of suspected reflux\u2010related cough.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.14775","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:09:16Z","timestamp":1709251756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Proximal esophageal impedance baseline increases the yield of impedance\u2010pH and is associated with response to PPIs in chronic cough patients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-1758","authenticated-orcid":false,"given":"Mentore","family":"Ribolsi","sequence":"first","affiliation":[{"name":"Department of Digestive Diseases Campus Bio Medico University of Rome  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-1060","authenticated-orcid":false,"given":"Nicola","family":"De\u00a0Bortoli","sequence":"additional","affiliation":[{"name":"Department of New Technologies and Translational Research in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-1563","authenticated-orcid":false,"given":"Marzio","family":"Frazzoni","sequence":"additional","affiliation":[{"name":"Digestive Pathophysiology Unit Azienda Ospedaliero\u2010Universitaria di Modena Ospedale Civile di Baggiovara  Modena 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