{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:54:02Z","timestamp":1773384842383,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dyspepsia is a prevalent condition in the general population. Besides organic causes, the differential diagnosis of dyspepsia includes functional dyspepsia (FD) and gastroparesis (GP) which share similar pathophysiological mechanisms and clinical presentation. So far, no study investigated the prevalence of FD and GP in a primary care in Belgium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from Intego, a Flemish\u2010Belgian general practice\u2010based morbidity registration network. From 586,164 patients between 2000 and 2021, we selected patients with ICD\u201010 code for FD and GP. Patients with organic gastrointestinal diseases were excluded. We determined demographics and comorbidities of FD\/GP. For prevalence and incidence calculation, we included those who consulted their general practitioners at least once in the given year. Pair\u2010wise comparison was conducted to access the impact of comorbidities on risk of FD\/GP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Between 2011 and 2021, the prevalence of FD\/GP ranged from 1.03% to 1.21%. The incidence of FD\/GP ranged from 109 to 142 per 100,000 adults. In total 5242 cases of FD\/GP were identified. These cases shared commonly coexisting diagnoses of gastroesophageal reflux disease (18.8%), irritable bowel syndrome (17.1%), and chronic constipation (18.7%). Patients with somatization\/anxiety\/depression had significantly higher risk of FD\/GP, compared to the control (OR 1.38, 95% CI 1.19\u20131.61, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>The prevalence (1.03%\u20131.21%) and incidence (109\u2013142\/100,000) of FD\/GP in primary care over last decade appear to conflict with epidemiological research in the general population. The discrepancies suggest a potential lack of awareness of FD and GP among physicians and\/or patients in Flemish\u2010Belgium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14778","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:14:11Z","timestamp":1710130451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiology of functional dyspepsia and gastroparesis as diagnosed in <scp>Flemish\u2010Belgian<\/scp> primary care: A registry\u2010based study from the Intego database"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-6180","authenticated-orcid":false,"given":"I\u2010Hsuan","family":"Huang","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders University of Leuven  Leuven Belgium"},{"name":"Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolien","family":"Schol","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-2294","authenticated-orcid":false,"given":"Yaozhu J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Global Evidence and Outcomes, Takeda Development Center Americas, Inc.  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