{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:56:26Z","timestamp":1792565786268,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peroral endoscopic myotomy (POEM) is an effective and safe treatment for achalasia, but often leads to posttreatment gastroesophageal reflux disease. The aim of this study was to examine the incidence and severity of reflux esophagitis after POEM and to identify associated predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent POEM between August 2011 and December 2022 were included. Multivariate logistic regression was used to assess predictive factors for reflux esophagitis after POEM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      In total, 252 patients were included; of which, 46% were female and age ranged between 18 and 87\u2009years. Reflux esophagitis within 1\u2009year after POEM was observed in 131 patients (52%), which was severe in 29 patients (LA grade C\/D, 12%). Length of full\u2010thickness myotomy (cm; OR 1.11, 95% CI 1.02\u20131.21), Eckardt scores before POEM (OR 0.84, 95% CI 0.74\u20130.96), previous pneumatic dilation (OR 0.51, 95% CI 0.29\u20130.91), and previous laparoscopic Heller myotomy (LHM; OR 0.44, 95% CI 0.23\u20130.86) were associated with reflux esophagitis after POEM. Alcohol use (none vs &gt;\u20097\u2009units per week; OR 3.51, 95% CI 1.35\u20139.11) and overweight (BMI \u226525\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; OR 2.67, 95% CI 1.17\u20136.09) were positive predictive factors and previous LHM (OR 0.13, 95% CI 0.02\u20130.95) was a negative predictive factor for severe reflux esophagitis after POEM (LA grade C\/D).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>About half of the patients develop reflux esophagitis after POEM and 12% is graded as severe. Recognizing predictive factors of reflux esophagitis after POEM treatment leads to better patient selection before POEM and provides an opportunity to take preventive measures or start preemptive treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.14794","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T06:29:53Z","timestamp":1712557793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Incidence and risk factors of reflux esophagitis after peroral endoscopic myotomy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3721-8279","authenticated-orcid":false,"given":"Elise M.","family":"Wessels","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology &amp; Metabolism  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen M. C.","family":"Masclee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology &amp; Metabolism  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A. J.","family":"Bastiaansen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology &amp; Metabolism  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fockens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology &amp; Metabolism  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology &amp; 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