{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:07Z","timestamp":1787169727938,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Irritable bowel syndrome (IBS) is a functional disorder commonly associated with extra\u2010intestinal symptoms. However, the prevalence of these symptoms according to IBS subtype is not well established.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To compare the prevalence of extra\u2010intestinal symptoms among patients with different subtypes of IBS.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A descriptive cross\u2010sectional study including patients with IBS according to Rome IV criteria was performed between July 2022 and April 2023. Patients were classified according their subtype of IBS: IBS\u2010D (diarrhea\u2010predominant), IBS\u2010C (constipation\u2010predominant), and IBS\u2010M (mixed bowel habits). Patients completed the IBS severity scoring system questionnaire (IBS\u2010SSS) to determine severity of IBS symptoms and patient health questionnaire\u2010 9 (PHQ\u20109) to define presence and severity of depressive symptoms. The prevalence of reported extra\u2010intestinal symptoms was also assessed and compared between groups.<\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n A total of 4862 patients with IBS were included; 608 IBS\u2010D (12.5%), 1978 IBS\u2010C (40.7%), and 2276 IBS\u2010M (46.8%). Patients with IBS\u2010C had significantly lower IBS\u2010symptoms severity (mean IBS\u2010SSS 290 vs. 310 and 320 for IBS\u2010D and IBS\u2010M, respectively,\n p<\/jats:italic>\n \u2009=\u20090.03). The prevalence of obesity was also significantly lower in these patients (17.1% vs. 30.9% IBS\u2010D and 27.9% IBS\u2010M,\n p<\/jats:italic>\n \u2009=\u20090.0001). Patients with IBS\u2010D showed a significantly higher prevalence of food intolerance perception (9.5%,\n p<\/jats:italic>\n \u2009=\u20090.03), history of cholecystectomy (17.8%,\n p<\/jats:italic>\n \u2009=\u20090.03), and fecal incontinence (36.2%,\n p<\/jats:italic>\n \u2009=\u20090.0001) as compared to the other groups. Patients with IBS\u2010M had significantly higher mean PHQ\u20109 score (12.7 vs. 11.1 IBS\u2010D and 10.5 IBS\u2010C,\n p<\/jats:italic>\n \u2009=\u20090.001) and prevalence of depressive symptoms (80.0%,\n p<\/jats:italic>\n \u2009=\u20090.01). Patients with IBS\u2010M also had higher prevalence of extra\u2010intestinal symptoms such as arthralgia (62.4%,\n p<\/jats:italic>\n \u2009=\u20090.0001), extremity numbness (64.5%,\n p<\/jats:italic>\n \u2009=\u20090.0001), atopic dermatitis (28.2%,\n p<\/jats:italic>\n \u2009=\u20090.02), and chronic cervicalgia (81.0%,\n p<\/jats:italic>\n \u2009=\u20090.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n The prevalence of most extra\u2010intestinal symptoms is higher among patients with IBS\u2010M. Further research is needed to better characterize IBS subtypes, which could potentially help refining tailored therapeutic strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.14796","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T06:35:00Z","timestamp":1712903700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of extra\u2010intestinal symptoms according to irritable bowel syndrome subtype"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5914-2484","authenticated-orcid":false,"given":"Facundo","family":"Pereyra","sequence":"first","affiliation":[{"name":"Gastroenterology Department Cipoletti Hospital R\u00edo Negro Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Mar\u00eda","family":"Bustos\u00a0Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Bustos Fern\u00e1ndez Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Schlottmann","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital Alem\u00e1n Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Zamora","sequence":"additional","affiliation":[{"name":"Department of Medical Strategy MEDICUS Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Marconi","sequence":"additional","affiliation":[{"name":"University Health Services (UHS) UW\u2010Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Carlos Durand Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisandro","family":"Pereyra","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Alem\u00e1n Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14569"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.12.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.2.113"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16589"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2022.2031281"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221114558"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2019.101634"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16214"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14161"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.021"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14546"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13074"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.3.298"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004453"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602367"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051878"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2022.102285"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0502-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034802"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01593-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16220"}],"container-title":["Neurogastroenterology 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