{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:08:44Z","timestamp":1769515724622,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Absent \u201corganic\u201d disease, dyspeptic symptoms may arise from abnormal gastric sensation, accommodation, motility or emptying (GE). Extensive gastric sensorimotor evaluation is rarely undertaken because testing is prolonged, invasive, poorly tolerated or unavailable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate whether gastric antral motor function, evaluated with scintigraphy, predicts GE. To explore whether motor testing with symptom recording predicts day\u2010to\u2010day symptoms in patients with dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GE was determined using a scintigraphic solid\u2010meal protocol (296\u2009kcal, 35% fat). Antral motility was estimated from 10\u2009min of scintigraphic time\u2010activity curves acquired 40\u2009min after meal consumption. An antral motility index (MI) was derived from contraction amplitude and frequency. Intra\u2010gastric distribution of the meal on scintograms at 1\u2009h (IGD1) was determined. Meal\u2010induced symptoms were evaluated by questionnaire. Patients completed the Gastroparesis Cardinal Symptom Index Daily Diary (GCSI\u2010DD) for 14\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve healthy participants and 23 prospectively recruited patients completed the study. Nine patients had delayed, and 2 had rapid, GE. In univariate analysis MI explained 42% of GE half\u2010time. In multivariate analysis MI and GE half\u2010time explained 25% of the variance in meal\u2010induced symptoms. While scintigraphic evaluation of gastric motor function with symptom recording explained 80% of the variance in the GCSI\u2010DD, meal\u2010induced symptoms were the only significant predictor. However, among patients with delayed GE, MI, GE half\u2010time, IGD1, and meal\u2010induced symptoms all significantly predicted GCSI\u2010DD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antral motility predicts GE. In exploratory analyses, only meal\u2010induced symptoms predicted daily symptoms among patients with dyspepsia. However, motor function also predicted symptoms in patients with delayed GE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14819","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T04:59:30Z","timestamp":1717131570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Extensive scintigraphic gastric motor function testing with concurrent symptom recording predicts prospectively measured daily dyspeptic symptoms"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-1161","authenticated-orcid":false,"given":"Xiao Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Division of Nuclear 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