{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:35:04Z","timestamp":1783085704910,"version":"3.54.6"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parkinson's disease (PD) is the second most common neurodegenerative disorder, and more than 80% of PD patients will develop oropharyngeal dysphagia. Despite its striated histology, proximity to airway, and potential negative impact of its dysfunction on bolus transport and airway safety, the contractile function of the striated esophagus in PD patients has not been systematically studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using our repository of clinical manometry and the Milwaukee ManoBank, we analyzed high\u2010resolution manometry (HRM) studies of 20 PD patients, mean age 69.1 (range 38\u201387\u2009years); 30 non\u2010PD patients with dysphagia, mean age 64.0 (44\u201386\u2009years); and 32 healthy volunteers, mean age 65.3 (39\u201386\u2009years). Patients with abnormal findings based on Chicago Classification 4.0 were identified. Repeat analysis was performed in 20% of the manometric tracings by a different investigator with inter\u2010rater concordance between 0.91 and 0.99.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The striated esophageal contractile integral in PD patients was significantly lower than that in non\u2010PD dysphagic patients and healthy controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.03 and &lt;0.01, respectively). This significant difference persisted after excluding patients with concurrent Chicago Classification motility disorders (<jats:italic>p<\/jats:italic>\u2009=\u20090.02 and 0.01, respectively). In both analyses, the distal esophageal contractile integral did not show any significant difference between groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.58 and 0.93, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>PD is associated with a significant decrease in striated esophagus contractility compared to non\u2010PD and healthy controls. This finding may play a pathophysiologic role in development of dysphagia in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14822","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T06:19:48Z","timestamp":1716790788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parkinson's disease is associated with low striated esophagus contractility potentially contributing to the development of dysphagia"],"prefix":"10.1111","volume":"36","author":[{"given":"Alexander","family":"Kerschner","sequence":"first","affiliation":[{"name":"Department of Internal Medicine The Hub for Collaborative Medicine, Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology The Hub for Collaborative Medicine, 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