{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:17:56Z","timestamp":1789039076771,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A diet low in fermentable oligo\u2010, di\u2010, monosaccharides and polyols (LFD) improves symptoms in patients with irritable bowel syndrome (IBS). Previous studies have focused on patients with IBS and diarrhea (IBS\u2010D). It is unclear whether LFD is effective for IBS with constipation (IBS\u2010C) or IBS with mixed bowel habits (IBS\u2010M). This open\u2010label, real\u2010world study evaluates the relative effectiveness of the LFD among IBS subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study analyzes data from a service that provides low\u2010FODMAP meals to individuals with IBS. Participants met with a registered dietitian and completed the IBS symptom severity survey (IBS\u2010SSS) before and after undergoing a 2\u20134\u2010week period of FODMAP restriction. The primary endpoint was the proportion of participants with \u226550\u2010point decrease in IBS\u2010SSS between the three IBS subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>After FODMAP restriction, 90% of participants with IBS\u2010D, 75% with IBS\u2010C, and 84% with IBS\u2010M met the primary endpoint (<jats:italic>p<\/jats:italic>\u2009=\u20090.045). Similar improvement was seen for a 100\u2010point decrease, but the difference between IBS subtypes was not significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.46). After FODMAP restriction, all groups had statistically significant improvement in total IBS\u2010SSS as well as individual symptom categories. Improvement in IBS\u2010SSS subcategories was similar among the groups except for the categories of bloating severity (IBS\u2010M had greatest improvement) and bowel movement satisfaction (IBS\u2010C had less improvement).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>Though the proportion of responders was highest for IBS\u2010D and lowest for IBS\u2010C, the LFD led to robust improvement in overall symptoms in all IBS subtypes. Key individual symptoms also showed significant improvements in all IBS subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14845","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T05:18:06Z","timestamp":1718687886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A diet low in fermentable oligo\u2010, di\u2010, monosaccharides and polyols improves abdominal and overall symptoms in persons with all subtypes of irritable bowel syndrome"],"prefix":"10.1111","volume":"36","author":[{"given":"Gregory","family":"Dean","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Chey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Chey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0286-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02183.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325214"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14051"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001767"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.248"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.099"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.054"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i25.4632"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311339"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.434"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.046"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122856"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i43.16215"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14229"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665120006990"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15410"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab005"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.010"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T15:47:25Z","timestamp":1723477645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/nmo.14845"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14845","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]},"assertion":[{"value":"2024-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14845"}}