{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:42:09Z","timestamp":1791358929849,"version":"4.3.1"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between gut microbiota and irritable bowel syndrome (IBS) subtype is unclear. We aimed to explore whether differences in fecal bacteria composition and short\u2010chain fatty acid (SCFA) levels were associated with subtypes and symptoms of IBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All participants delivered fecal samples and self\u2010reports on IBS Symptom Severity Score (IBS\u2010SSS), Bristol Stool Scale (BSS), and Gastrointestinal Symptom Rating Scale (GSRS). Fecal bacteria composition was assessed by the GA\u2010map\u00ae Dysbiosis Test based on 16S rRNA sequences of bacterial species\/groups. SCFAs were analyzed by vacuum distillation followed by gas chromatography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Sixty patients with IBS were included (mean age 38\u2009years, 46 [77%] females): Twenty\u2010one patients were classified as IBS\u2010D (diarrhea), 31 IBS\u2010M (mixed diarrhea and constipation), and eight IBS\u2010C (constipation). Forty\u2010two healthy controls (HCs) (mean age 35\u2009years, 27 [64%] females) were included. Patients had a significantly higher relative frequency of dysbiosis, lower levels of Actinobacteria, and higher levels of\n                      <jats:italic>Bacilli<\/jats:italic>\n                      than HCs. Eight bacterial markers were significantly different across IBS subgroups and HCs, and 13 bacterial markers were weakly correlated with IBS symptoms.\n                      <jats:italic>Clostridia<\/jats:italic>\n                      and\n                      <jats:italic>Veillonella<\/jats:italic>\n                      spp. had a weak negative correlation with constipation scores (GSRS) and a weak positive correlation with loose stools (BSS). Diarrhea scores (GSRS) and looser stool (BSS) were weakly correlated with levels of total SCFAs, acetic and butyric acid. Levels of total SCFAs and acetic acid were weakly correlated with symptom severity (IBS\u2010SSS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>Patients with IBS had a different fecal bacteria composition compared to HCs, and alterations of SCFAs may contribute to the subtype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.14854","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T02:10:15Z","timestamp":1719799815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fecal bacteria and short\u2010chain fatty acids in irritable bowel syndrome: Relations to subtype"],"prefix":"10.1111","volume":"36","author":[{"given":"Erica Sande","family":"Teige","sequence":"first","affiliation":[{"name":"Centre for Nutrition, Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"National Centre for Functional Gastrointestinal Disorders, Department of Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-294X","authenticated-orcid":false,"given":"Eline Margrete Randulff","family":"Hillestad","sequence":"additional","affiliation":[{"name":"Centre for Nutrition, Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"National Centre for Functional Gastrointestinal Disorders, Department of Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Kjelsvik","family":"Steinsvik","sequence":"additional","affiliation":[{"name":"National Centre for Functional Gastrointestinal Disorders, Department of Medicine Haukeland University Hospital  Bergen 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