{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:45:28Z","timestamp":1789497928379,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric sensorimotor disorders (functional dyspepsia [FD] and gastroparesis [GP]) are prevalent and burdensome. Prolonged ambulatory recording using a wireless patch may provide novel information in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive adult patients (age\u2009\u2265\u200918\u2009years) referred for gastric emptying scintigraphy (GES) were eligible for study inclusion. Patients were excluded if they had prior foregut surgery; were taking opioids or other medications known to affect gastric emptying; had a HgbA1C\u2009&gt;\u200910; or were recently hospitalized. Three wireless motility patches were applied to the skin prior to GES. Patients wore the patches for 6\u2009days while recording meals, symptoms, and bowel movements using an iPhone app.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Twenty\u2010three consecutive adults (87% women; mean age\u2009=\u200943.9\u2009years; mean BMI\u2009=\u200926.7\u2009kg\/m<jats:sup>2<\/jats:sup>) were enrolled. A gastric histogram revealed three levels of gastric myoelectric activity: weak, moderate, and strong. Patients with delayed gastric emptying at 4\u2009h had weak gastric myoelectrical activity. Patients with nausea and vomiting had strong intestinal activity. Those with FD had weak gastric and intestinal myoelectric activity, and a weak meal response in the stomach, intestine, and colon compared to those with nausea alone or vomiting alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Patients with FD, and those with delayed gastric emptying, had unique gastrointestinal myoelectrical activity patterns. Reduced postprandial pan\u2010intestinal myoelectric activity may explain the symptoms of FD in some patients. Recording gastrointestinal activity over a prolonged period in the outpatient setting has the potential to identify unique pathophysiologic patterns and meal\u2010related activity that distinguishes patients with distinct gastric sensorimotor disease states.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14862","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T14:10:55Z","timestamp":1721657455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A novel pilot study to evaluate the efficacy and safety of a wireless patch system in patients with chronic nausea and vomiting"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-7970","authenticated-orcid":false,"given":"Brian E.","family":"Lacy","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-7012","authenticated-orcid":false,"given":"David J.","family":"Cangemi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Accurso","sequence":"additional","affiliation":[{"name":"Division of Nuclear Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Axelrod","sequence":"additional","affiliation":[{"name":"G\u2010Tech Medical, Inc.  Mountain View California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Axelrod","sequence":"additional","affiliation":[{"name":"G\u2010Tech Medical, Inc.  Mountain View California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-6064","authenticated-orcid":false,"given":"Anand","family":"Navalgund","sequence":"additional","affiliation":[{"name":"G\u2010Tech Medical, Inc.  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