{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:50:34Z","timestamp":1788918634523,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A subset of patients with irritable bowel syndrome (IBS) develop their symptoms after gastroenteritis, referred to as postinfectious IBS (PI\u2010IBS). PI\u2010IBS is associated with low\u2010grade intestinal inflammation. Previous studies have evaluated mesalamine, an anti\u2010inflammatory drug, in patients with IBS. We evaluated the efficacy of long\u2010acting mesalamine in patients with PI\u2010IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010one patients who developed diarrhea\u2010predominant IBS (IBS\u2010D) after gastroenteritis were randomized to receive either 2.4\u2009g of long\u2010acting mesalamine or placebo daily for 8\u2010weeks. The symptoms assessed were abdominal pain, bloating, stool frequency, stool consistency, severity of diarrhea and constipation, satisfaction with bowel habits, and IBS affecting or interfering with life. Quality\u2010of\u2010life (QOL) was assessed using the IBS\u2010QOL questionnaire. The prespecified primary outcome variable was the overall bowel symptom score (BSS) after 8\u2010weeks of treatment. Effect sizes were expressed as standardized mean differences (Cohen's <jats:italic>d<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four patients completed the 8\u2010week treatment (<jats:italic>n<\/jats:italic>\u2009=\u200928 mesalamine, <jats:italic>n<\/jats:italic>\u2009=\u200926 placebo), 49 (91%) were male, and age range 23\u201371\u2009years (mean\u2009\u00b1\u2009SD 43\u2009\u00b1\u200913). Mesalamine demonstrated superior efficacy compared to placebo on the primary outcome variable, overall BSS (Cohen's <jats:italic>d<\/jats:italic>\u2009=\u20090.57, <jats:italic>p<\/jats:italic>\u2009=\u20090.042). Mesalamine was also superior for the secondary outcome of how much IBS affects your life in general (<jats:italic>d<\/jats:italic>\u2009=\u20090.72, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). For the secondary outcomes of IBS symptoms, 7 of the 7 symptoms had trends of mesalamine superiority. For the secondary outcomes of IBS\u2010QOL subscales, 8 of 9 had trends of mesalamine superiority.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with PI\u2010IBS, long\u2010acting mesalamine demonstrated to be effective in reducing IBS symptoms and improving QOL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14889","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T05:10:28Z","timestamp":1722921028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Randomized double\u2010blind placebo\u2010controlled study to evaluate the effect of long\u2010acting mesalamine on postinfectious irritable bowel syndrome with diarrhea"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-1976","authenticated-orcid":false,"given":"Ashok K.","family":"Tuteja","sequence":"first","affiliation":[{"name":"George E. Whalen Veterans Affairs Medical Center  Salt Lake City Utah USA"},{"name":"Divisions of Gastroenterology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Leung","sequence":"additional","affiliation":[{"name":"Infectious Diseases University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Fang","sequence":"additional","affiliation":[{"name":"Divisions of Gastroenterology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5586-8606","authenticated-orcid":false,"given":"Nicholas. J.","family":"Talley","sequence":"additional","affiliation":[{"name":"University of Newcastle  Callaghan New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Stoddard","sequence":"additional","affiliation":[{"name":"Epidemiology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00324-X"},{"key":"e_1_2_10_4_1","first-page":"307","article-title":"The irritable colon syndrome. 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