{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:07:14Z","timestamp":1785179234755,"version":"3.55.0"},"reference-count":97,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity and diabetes are associated with altered gastrointestinal function and with the development of abdominal pain, nausea, diarrhea, and constipation among other symptoms. The enteric nervous system (ENS) regulates gastrointestinal motility. Enteric neuropathies defined as damage or loss of enteric neurons can lead to motility disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Here, we review the molecular mechanisms that drive enteric neurodegeneration in diabetes and obesity, including signaling pathways leading to neuronal cell death, oxidative stress, and microbiota alteration. We also highlight potential approaches to treat enteric neuropathies including antioxidant therapy to prevent oxidative stress\u2010induced damage and the use of stem cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14897","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T06:30:19Z","timestamp":1723185019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular mechanisms of enteric neuropathies in high\u2010fat diet feeding and diabetes"],"prefix":"10.1111","volume":"37","author":[{"given":"Francesca","family":"Cingolani","sequence":"first","affiliation":[{"name":"Division of Digestive Diseases Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Atlanta Veterans Affairs Health Care System  Decatur Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Atlanta Veterans Affairs Health Care System  Decatur Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-2369","authenticated-orcid":false,"given":"Shanthi","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Atlanta Veterans Affairs Health Care System  Decatur Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71908-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S67400"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"issue":"7","key":"e_1_2_12_6_1","first-page":"s176","article-title":"Obesity: definition, comorbidities, causes, and burden","volume":"22","author":"Apovian CM","year":"2016","journal-title":"Am J Manag Care"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00690-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010111"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12330"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.213"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-27592-5_12"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1681-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901844R"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13838"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130176"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.78"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26295"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03812-y"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021317-121515"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0129-9"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8024171"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20082003"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2022"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00423-7"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45040232"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12754"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.05.011"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01165-z"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.810483"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.18"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00385-2"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.053"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13745"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273269"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.09.033"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.693150"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i6.794"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1553"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2132-9"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i41.7359"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.12.008"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12630"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2011.06.003"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01379.x"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.07.050"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00227.2020"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-022-05199-8"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2024.01.006"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szad063"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2015.0095"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01611.x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102759"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081413"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0905-9"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114044"},{"issue":"1","key":"e_1_2_12_56_1","article-title":"Intestinal region\u2010dependent alterations of toll\u2010like receptor 4 expression in myenteric neurons of type 1 diabetic rats","volume":"11","author":"Bodi N","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.003"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.02.014"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.09.001"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.046"},{"issue":"1","key":"e_1_2_12_61_1","first-page":"62","article-title":"Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis","volume":"11","author":"Grover M","year":"2018","journal-title":"BMC Med Genet"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00115.2019"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.07.003"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.11.007"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz061"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000209"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104821"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-019-03002-0"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131672"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00009.2018"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094564"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10010142"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.617036"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.02.033"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i22.3440"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00774.x"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01018.x"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01023.x"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01780.x"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00085.2016"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14688"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26634-9"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14045"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.226"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15937"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16951"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731420905701"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4233"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.08.009"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12874"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-022-00390-z"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01311-0"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500602"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.03.025"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1265372"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.06.034"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14477"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.06.010"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:59:28Z","timestamp":1753347568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":97,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/nmo.14897"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14897","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]},"assertion":[{"value":"2024-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14897"}}