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It has been proposed that CVS and migraine may share pathophysiologic mechanisms of hypothalamic activation and altered dopaminergic signaling, and impaired sensorimotor intrinsic connectivity. The past decade has brought groundbreaking advances in the treatment of migraine and other headache disorders. While many of these therapies have yet to be studied in episodic syndromes associated with migraine including CVS and abdominal migraine, the potential shared pathophysiology among these conditions suggests that use of migraine\u2010specific treatments may have a beneficial role even in those for whom headache is not the primary symptom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This manuscript highlights newer therapies in migraine. Calcitonin gene\u2010related peptide (CGRP) and its relation to migraine pathophysiology and the therapies that target the CGRP pathway, as well as a 5HT1F receptor agonist and neuromodulation devices used to treat migraine are briefly discussed as they may potentially prove to be useful in the future treatment of CVS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14899","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T10:48:47Z","timestamp":1723459727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evidence\u2010based review and frontiers of migraine therapy"],"prefix":"10.1111","volume":"37","author":[{"given":"Kaitlin A.","family":"Greene","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy 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