{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:21:42Z","timestamp":1791357702394,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010721","name":"Ironwood Pharmaceuticals, Incorporated","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome (IBS) is a disorder of gut\u2013brain interaction characterized by abdominal pain and altered bowel habits, with patient\u2010perceived dissatisfaction of treatment symptom control. We assessed disease burden, satisfaction with medication use, and impact on activities, in participants with IBS with constipation (IBS\u2010C) and diarrhea (IBS\u2010D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study assessed data from a large, United States survey of adults querying demographics, comorbid conditions, quality of life, medication use, satisfaction with symptom control, and work productivity. Participants were grouped into the IBS\u2010C or IBS\u2010D cohort if they met Rome IV criteria, with controls matched 1:1 according to age, sex, race, region, and Charlson Comorbidity Index score. All data were self\u2010reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Nine hundred and ten participants with IBS\u2010C and 669 with IBS\u2010D were matched to controls. The most reported symptoms were abdominal discomfort for IBS\u2010C and abdominal pain and abdominal discomfort for IBS\u2010D. Among the IBS\u2010C and IBS\u2010D cohorts, 74.2% and 65.9%, respectively, took prescription and\/or over\u2010the\u2010counter medication for their symptoms. Respondents were more dissatisfied than satisfied with control of their symptoms. Respondents taking prescription medication(s) with or without over\u2010the\u2010counter medication(s) reported better symptom control than respondents only taking over\u2010the\u2010counter medications (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was significantly higher mean presenteeism, work productivity loss, and daily activity impairment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all) in respondents with IBS compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>This study provides insight into respondents' experiences of IBS symptoms, including the impact on daily activity, as well as satisfaction with control of symptoms and prescription and over\u2010the\u2010counter medications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14903","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T06:50:18Z","timestamp":1725346218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Burden of illness and treatment attitudes among participants meeting Rome <scp>IV<\/scp> criteria for irritable bowel syndrome: A nationwide survey in the United States"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-7970","authenticated-orcid":false,"given":"Brian E.","family":"Lacy","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Xu","sequence":"additional","affiliation":[{"name":"AbbVie Inc  North Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C. A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Former employee of Ironwood Pharmaceuticals  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Kosch","sequence":"additional","affiliation":[{"name":"AbbVie Inc  North Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Dobrescu","sequence":"additional","affiliation":[{"name":"Acumen Health Research Institute  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Morlock","sequence":"additional","affiliation":[{"name":"Acumen Health Research Institute  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Morlock","sequence":"additional","affiliation":[{"name":"YourCareChoice  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceciel","family":"Rooker","sequence":"additional","affiliation":[{"name":"International Foundation for Gastrointestinal Disorders  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17132"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30217-X"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.358"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12938"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2016.1253584"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2016.16138"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16484"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0611-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15325"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.16067"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.04.032"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001036"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14070"},{"issue":"1","key":"e_1_2_12_19_1","first-page":"S53","article-title":"Review article: current and future treatment approaches for IBS with constipation","volume":"54","author":"Liu JJ","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"e_1_2_12_20_1","first-page":"S35","article-title":"Evidence\u2010based management of irritable bowel syndrome with diarrhea","volume":"24","author":"Pimentel M","year":"2018","journal-title":"Am J Manag Care"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i22.6759"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2019-101298"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.10.036"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0733-x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2020.1799816"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2016-000094"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2014.919926"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_12_31_1","unstructured":"IqbalSU RogersW SelimA et\u00a0al.The Veterans RAND 12 Item Health Survey (VR\u201012): what it is and how it is used.2007Accessed November 2022.https:\/\/www.bu.edu\/sph\/files\/2015\/01\/veterans_rand_12_item_health_survey_vr\u201012_2007.pdf"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9866-y"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.08.016"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618787648"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:46:30Z","timestamp":1730893590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/nmo.14903"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14903","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"2024-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14903"}}