{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:45:31Z","timestamp":1788561931768,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of small bowel motility disorders is performed by manometric evaluation of the contractile patterns of the small intestine. Conventional intestinal manometry systems include few pressure sensors at relatively long intervals. We have recently shown that high\u2010resolution jejunal manometry, with multiple closely spaced recording sites, allows the analysis of propagation patterns of intestinal motility in healthy subjects that cannot be detected with conventional manometry. The objective of this pilot study was to explore the feasibility and diagnostic value of high\u2010resolution intestinal manometry in patients with suspected small bowel dysmotility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective pilot study evaluating intestinal motility patterns in 16 consecutive patients (16\u201361\u2009years; 11 women) with severe, chronic digestive symptoms referred for the evaluation of intestinal motility and in 18 healthy controls (21\u201338\u2009years; 8 women). A 36\u2010channel high\u2010resolution manometry catheter was orally placed under radiological guidance in the jejunum. Intestinal motility was continuously recorded for 3\u2009h fasting and 2\u2009h after a 450\u2009kcal meal. The manometric recordings were analyzed in two formats: (a) with the high\u2010resolution data from 34 channels and (b) showing only the recordings from 5 channels separated by 7\u2009cm intervals, mimicking a conventional manometry recording.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In the analysis mimicking conventional manometry, abnormal motility criteria were detected in six patients and in no healthy subject [bursts (<jats:italic>n<\/jats:italic>\u2009=\u20093), postprandial minute rhythm (<jats:italic>n<\/jats:italic>\u2009=\u20091) and myopathic pattern (<jats:italic>n<\/jats:italic>\u2009=\u20092)]. These classical dysmotility criteria were also detected by high\u2010resolution manometry. High\u2010resolution analysis detected one or more abnormal findings in seven additional patients that were not observed in any healthy subject, specifically: (a) abnormal propagation of Phase III (<jats:italic>n<\/jats:italic>\u2009=\u20093); (b) reduced propagated activity during Fasting Phase II (<jats:italic>n<\/jats:italic>\u2009=\u20094); (c) increased propagated activity during Fasting Phase II and postprandial phase (<jats:italic>n<\/jats:italic>\u2009=\u20091).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>This pilot study suggests that high\u2010resolution intestinal manometry may improve the sensitivity of conventional manometry in the detection of intestinal motor dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14907","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T05:46:03Z","timestamp":1725342363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High\u2010resolution versus conventional manometry for the diagnosis of small bowel motor dysfunction"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-1539","authenticated-orcid":false,"given":"L. G.","family":"Alcala\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Digestive System Research Unit University Hospital Vall d'Hebron  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Digestive System Research Unit University Hospital Vall d'Hebron  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Accarino","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Digestive System Research Unit University Hospital Vall d'Hebron  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-960X","authenticated-orcid":false,"given":"F.","family":"Azpiroz","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Digestive System Research Unit University Hospital Vall d'Hebron  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Malagelada","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Digestive System Research Unit University Hospital Vall d'Hebron  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01230.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13239"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.1.5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12170"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18112"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14240"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14351"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13835"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00539.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301145"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.159"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.06.037"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13219"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.084"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12669"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.05.001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520902839642"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:46:50Z","timestamp":1730893610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/nmo.14907"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14907","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"2023-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14907"}}