{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:25:29Z","timestamp":1777674329993,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Supplementation with the <jats:italic>Agave tequilana<\/jats:italic> Weber blue variety fructans is a feasible treatment option for functional constipation (FC). However, its effects on colonic function have not yet been studied. This study assessed whole gut transit time (WGTT) and regional transit time using a wireless motility capsule (WMC) before and after supplementation with different fiber treatments in patients with FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A secondary analysis was performed on data collected from a randomized, double\u2010blind clinical trial comparing agave fructans with psyllium plantago. WGTT, regional transit time, contractility, and pH were measured using WMC before and after fiber supplementation. Comparisons were performed using nonparametric tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Twenty patients with FC were evaluated, with a median age of 39 (25\u201354\u2009years), and 18 (90%) were women. Five patients were included in each intervention group. There were no changes in WGTT or regional transit times between the groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Similarly, there were no differences in the changes experienced by regional or general contractility among the groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The cecal pH profile did not differ between the groups before and after fiber supplementation (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The percentages of clinical responses and consistency of bowel movements between the groups were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>FC presents a clinical response to a fiber challenge, regardless of the administered intervention. However, this response was not associated with improvement in contractility or regional transit time. We speculate that there are other mechanisms by which fiber consumption may improve FC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14908","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T05:26:03Z","timestamp":1725341163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of fiber supplementation with agave fructans or psyllium plantago in symptoms of constipation and its relation with whole and regional transit time and <scp>pH<\/scp>"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-2792","authenticated-orcid":false,"given":"Enrique","family":"Coss\u2010Adame","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Motility Laboratory Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josealberto Sebastiano","family":"Arenas\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Motility Laboratory Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"},{"name":"School of Medicine Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Fernanda","family":"Garc\u00eda\u2010Cedillo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Motility Laboratory Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"},{"name":"School of Medicine Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Cassis","family":"Nosthas","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Bustillo\u2010Armendriz","sequence":"additional","affiliation":[{"name":"Bustar Alimentos S.A.P.I. de C.V  Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.95"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.18"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13647"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00433.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i29.8952"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.217331"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0000000000001888"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283x12437874"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01517.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2014.20.2.265"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12047"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.53"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02065421"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17782"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.75"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy041"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114517003440"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T11:47:25Z","timestamp":1730893645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/nmo.14908"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14908","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"2024-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14908"}}