{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:29Z","timestamp":1753879229196,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colonic transit (CT) measured by validated scintigraphy using <jats:sup>111<\/jats:sup>In\u2010labeled activated charcoal particles is summarized using geometric center (GC) of isotopic distribution in four colonic regions and stool at 24 and 48\u2009h. Diagnosis of rapid CT is currently based on GC24 \u22654.4 in females and &gt;4.7 in males, which lack sensitivity. Our aim was to evaluate, in patients with chronic diarrhea with normal CT by GC24 and GC48, the diagnostic utility of CT change (\u2206GC) relative to sex\u2010matched normal values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated two adult patient cohorts: 701 clinical patients (1994\u20132023) with chronic diarrhea and 76 research participants with irritable bowel syndrome with diarrhea (<jats:italic>N<\/jats:italic>\u2009=\u200963) or bile acid diarrhea (BAD, <jats:italic>N<\/jats:italic>\u2009=\u200913). Results of \u2206GC were compared to 220 healthy controls' 95th percentiles (%ile) (\u22652.0 females and\u2009\u22652.2 males). In the research cohort, we also analyzed (Spearman correlation) colonic \u2206GC with ascending colon emptying T<jats:sub>1\/2<\/jats:sub> (AC T<jats:sub>1\/2<\/jats:sub>), average stool frequency and consistency based on a daily diary, total fecal bile acid (BA) concentration, and % primary BA in a single stool sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Among 701 clinical patients with normal GC24, 160 (22.3%) had rapid CT based on \u2206GC 95th %ile in health. Among 76 research participants, an additional 20.6% IBS\u2010D and 23% BAD had rapid CT \u2206GC. Younger age and absence of diabetes mellitus were predictive of rapid \u2206GC. \u2206GC significantly correlated with AC T<jats:sub>1\/2<\/jats:sub> and with fecal BA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>\u2206GC identified an additional 21%\u201323% patients with rapid colonic transit among patients with diarrhea and normal GC24.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14917","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T07:50:34Z","timestamp":1726818634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Additional criteria on scintigraphic testing for diagnosis of rapid colonic transit in patients with chronic diarrhea"],"prefix":"10.1111","volume":"36","author":[{"given":"Camille","family":"Lupianez\u2010Merly","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-7405","authenticated-orcid":false,"given":"Saam","family":"Dilmaghani","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Jencks","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Eckert","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience 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