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In theory, this metric could be applied to evaluate the \u201cefficiency\u201d of brainstem pathways involved in common mechanisms of autonomic function involving the vagal influences on the gut as well as the heart. Thus, by exploring the dynamic \u201cefficiency\u201d of the brainstem feedback circuit linking heart rate to posture, a clinically relevant index of vagal flexibility might be extracted that would provide a generalizable window into the vagal regulation of both the heart and gut. Recent research supports this contention and has documented that this metric, VE, appears to covary with disorders of the gut. Clinical application of this metric might identify individual vulnerabilities that frequently reflect symptoms assumed to have features of a dysregulated autonomic nervous system (i.e., dysautonomia). If this is confirmed by additional research, then this objective measure of neural regulation of autonomic function might provide insight into the pathogenesis of disorders of gut\u2013brain interaction.<\/jats:p>","DOI":"10.1111\/nmo.14926","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:03:52Z","timestamp":1727676232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Disorders of gut\u2013brain interaction through the lens of polyvagal theory"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7293-2005","authenticated-orcid":false,"given":"Stephen W.","family":"Porges","sequence":"first","affiliation":[{"name":"Indiana University Bloomington  Bloomington Indiana USA"},{"name":"University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02183.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-010-1077-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01097.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.3.394"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10484-022-09559-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20871"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3071"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042320-014032"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1995.tb01213.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpnec.2023.100200"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2022.03.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5730.302-a"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.06.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/icd.688"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199612)29:8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0018-506X(02)00024-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1043"},{"key":"e_1_2_10_19_1","first-page":"629","volume-title":"Handbook of Life Stress, Cognition and Health","author":"Sterling P","year":"1988"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.037192"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195051063.003.0011"},{"key":"e_1_2_10_22_1","first-page":"1931","article-title":"A functional test of heart vagi in man","volume":"57","author":"Hering HE","year":"1910","journal-title":"Menschen Munchen Med Wochenschr"},{"key":"e_1_2_10_23_1","first-page":"708","volume-title":"Principles of Psychophysiology: Physical, Social, and Inferential Elements","author":"Porges SW","year":"1990"},{"key":"e_1_2_10_24_1","first-page":"510","article-title":"Method and apparatus for evaluating rhythmic oscillations in aperiodic physiological response systems","volume":"4","author":"Porges SW","year":"1985","journal-title":"US4510944A"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.11.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14165"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S004857729997035X"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21841"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-2302(199909)35"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.841749"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002207"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0360-3_7"},{"issue":"4","key":"e_1_2_10_33_1","first-page":"333","article-title":"Atropine sulfate effects on aviator performance and on respiratory\u2010heart period interactions","volume":"58","author":"Dellinger JA","year":"1987","journal-title":"Aviat Space Environ Med"}],"container-title":["Neurogastroenterology &amp; 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