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This study allows to evaluate their crosslink and to compare the aqueous extracts laxative actions of two edible wild fruits of <jats:italic>Arbutus unedo<\/jats:italic> (AUAE) and <jats:italic>Crataegus monogyna<\/jats:italic> (CMAE) in constipated high\u2010fat diet (HFD) rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Wistar<\/jats:italic> rats were divided into experimental groups for 13\u2009weeks: standard (SD) and HFD groups. SD\u2010rats were randomly redivided into 2 groups: SD and SD\u2009+\u2009Loperamide (LOP, 3\u2009mg\/kg, b.w.). HFD\u2010rats were randomly reseparated into HFD\u2010group, (HFD\u2009+\u2009LOP)\u2010group, [HFD\u2009+\u2009Yohimbine (YOH, 2\u2009mg\/kg, b.w.)]\u2010group, [HFD+ LOP]\u2010groups+ various doses of AUAE or CMAE (75, 150, and 300\u2009mg\/kg, b.w.). Diversified indicators were investigated to achieve the expected objectives, including; fecal parameters, gastrointestinal transit (GIT), gastric emptying (GE), oxidative stress\u2010(OxS), blood biochemical analysis, and accompanied small\/large bowel histological modification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The liquid chromatography\u2010electrospray ionization\u2010tandem mass spectrometry (LC\u2013ESI\u2013MS) analysis of AUAE and CMAE allowed the identification of 11 and 6 phenolic compounds, respectively. In HFD\u2010rats, the subsequent dysregulation of GI motility was markedly aggravated. More importantly, with the same way (CMAE and AUAE)\u2010treated groups showed alleviated outcomes for the following: most stool parameters, GIT, and GE were remarkably recovered; a similar recovery pattern was observed in the histopathological structure, OxS, and blood biochemical indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Our results experimentally confirmed the crosslink between overweight and constipation and both fruits have potential as functional foods to reduce metabolic risk of the obesity associated with bowel dysmotility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14933","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T12:05:22Z","timestamp":1727697922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overweight\/bowel dysmotility crosslinking and analogous laxative actions of two edible wild fruits in obese\/constipated rats"],"prefix":"10.1111","volume":"36","author":[{"given":"Soumaya","family":"Wahabi","sequence":"first","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kais","family":"Rtibi","sequence":"additional","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources  Beja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirine","family":"Brinsi","sequence":"additional","affiliation":[{"name":"University of Jendouba, Higher Institute of Biotechnology of Beja, LR: Functional Physiology and Valorization of Bio\u2010Resources  Beja 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