{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:37:52Z","timestamp":1754195872281,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Understanding the relationship between distal contractile integral (DCI) and mean nocturnal baseline impedance (MNBI) could shed light on new diagnostic and treatment strategies, specifically concerning nocturnal reflux. This study aimed to assess this relationship to enhance our comprehension of the interplay between esophageal contractility and mucosal permeability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified adult patients who had high resolution esophageal manometry and pH\u2010impedance tests performed within a 30\u2010day period between December 2018 and March 2022. A random forest model was used to identify significant predictors of MNBI, assisting with variable selection for a following regression analysis. Subsequently, both univariable and multivariable regression models were utilized to measure the association between predictors and MNBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Our study included 188 patients, primarily referred for testing due to reflux. The most common motility diagnoses were normal (62%) followed by possible esophagogastric junction outflow obstruction (22%). The mean DCI was 2020\u2009mmHg\u2219s\u2219cm and MNBI was 3.05\u2009k\u03a9. The random forest model identified 12 significant predictors for MNBI, key variables being acid exposure time (AET), total proximal reflux events, intraabdominal lower esophageal sphincter length, hiatal hernia presence, and DCI. Subsequent multivariable regression analyses demonstrated log AET (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.69, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;0.001), total proximal reflux events (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), hiatal hernia presence (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.014), log DCI (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20091.26, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and age (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.13, <jats:italic>p<\/jats:italic>\u2009=\u20090.036) as being significantly associated with MNBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>DCI is a key manometric predictor of MNBI emphasizing the role of manometry in detecting reflux risk and the need for its consideration in reflux management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14937","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T05:10:01Z","timestamp":1728277801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distal contractile integral and other key predictors of mean nocturnal baseline impedance: The role of esophageal peristaltic vigor in mucosal permeability"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-6192","authenticated-orcid":false,"given":"Ofer Z.","family":"Fass","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Stanford University School of Medicine  Redwood City California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8950-8916","authenticated-orcid":false,"given":"Afrin N.","family":"Kamal","sequence":"additional","affiliation":[{"name":"Division of 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