{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:24Z","timestamp":1753879344203,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Capsaicin\u2010containing red pepper sauce suspension augments esophageal contraction amplitude on conventional manometry. This study used high\u2010resolution manometry (HRM) to investigate if capsaicin infusion modulates segmental esophageal smooth muscle peristalsis in healthy adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen healthy volunteers (mean age 37\u2009years, 14 male) underwent HRM for the evaluation of primary peristalsis and secondary peristalsis using slow and rapid air distensions. Both primary and secondary peristalsis were assessed following infusions of capsaicin\u2010containing red pepper sauce and saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Capsaicin infusion significantly increased heartburn symptoms compared to saline infusion (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and significantly decreased threshold volumes of secondary peristalsis during rapid air distensions (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). The frequency of secondary peristalsis during rapid air distensions was significantly increased by capsaicin infusion (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Neither capsaicin infusion (<jats:italic>p<\/jats:italic>\u2009=\u20090.06) nor saline infusion (<jats:italic>p<\/jats:italic>\u2009=\u20090.27) altered threshold volume during slow air distensions. Capsaicin infusion significantly increased distal contractile integral (DCI) of primary peristalsis (<jats:italic>p<\/jats:italic>\u2009=\u20090.04), particularly in the proximal smooth muscle segment (<jats:italic>p<\/jats:italic>\u2009=\u20090.048). It enhanced secondary peristalsis during rapid air distensions (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) but not during slow air distension (<jats:italic>p<\/jats:italic>\u2009=\u20090.23). Saline infusion significantly increased DCI of secondary peristalsis during rapid air distension (<jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Augmentation of distension\u2010induced secondary peristalsis can be modulated by activation of capsaicin\u2010sensitive afferents similar to mechanosensitive afferents. Capsaicin\u2010induced augmentation of primary peristalsis isolates to the cholinergic\u2010mediated proximal smooth muscle segment, which warrants study in ineffective esophageal motility to determine therapeutic potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14942","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:22:33Z","timestamp":1728566553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of capsaicin on esophageal peristalsis in humans using high resolution manometry"],"prefix":"10.1111","volume":"36","author":[{"given":"Wei\u2010Yi","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui\u2010Sheng","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Wun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tso\u2010Tsai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsun","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. Prakash","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine  St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-8210","authenticated-orcid":false,"given":"Chien\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"},{"name":"Institute of Medical Sciences, Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402023100503"},{"key":"e_1_2_10_3_1","first-page":"E359","article-title":"Effect of thoracic vagotomy and vagal stimulation on esophageal function","volume":"234","author":"Kravitz JJ","year":"1978","journal-title":"Am J Phys"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.5.G1246"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.127993"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016967"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1996.94266000.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15170"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14267"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15641"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.071084"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200409000-00014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00947.x"},{"issue":"971","key":"e_1_2_10_15_1","article-title":"Evidence for neurotrophic factors associating with TRPV1 gene expression in the inflamed human esophagus","volume":"22","author":"Shieh KR","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01332.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12638"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07258.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01787.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13736"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018831018566"},{"key":"e_1_2_10_23_1","first-page":"419","article-title":"Capsaicin\u2010sensitive nerves mediate esophageal mucosal protection","volume":"110","author":"Bass BL","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80575-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00175.2014"},{"issue":"86","key":"e_1_2_10_26_1","first-page":"1231","article-title":"Vagal esophageal receptors in anesthetized dogs: mechanical and chemical responsiveness","volume":"1999","author":"Sekizawa S","year":"1985","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01222-X"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00793.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07110.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328303bff1"}],"container-title":["Neurogastroenterology &amp; 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