{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:18:02Z","timestamp":1776154682467,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a large unmet need for alternative, non\u2010invasive, and accurate diagnosis of small intestinal bacterial overgrowth (SIBO). The smart capsule bacterial detection system (SCBDS) device contains a targeted sampling technology and an onboard SCBDS assay to detect metabolically active bacteria in the small intestine. Here, we evaluated the agreement of SCBDS assay with duodenal aspiration\/culture ex\u00a0vivo in a multicenter clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Duodenal aspiration was performed in subjects with gastrointestinal symptoms suggestive of SIBO. Aspirated fluid was sent to local and central microbiology labs to evaluate the agreement for detecting bacteria with SCBDS assay compared to the total bacterial count (TBC) reference standard. The performance of SCBDS assay was evaluated using a receiver operator curve, sensitivities, and specificities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Aspirates from 66 patients were collected and analyzed for TBC and SCDBS assay. The overall agreement between the two assays was 82%\u201392% across 3 clinical sites. The SCBDS assay had a sensitivity of 67%\u2013100% and a specificity of 90%\u201397% using either \u2265\u200910<jats:sup>3<\/jats:sup> or 10<jats:sup>5<\/jats:sup>\u2009CFU\u2009mL<jats:sup>\u22121<\/jats:sup> cutoff. Additionally, there was a good correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.82) for the TBC culture between the local and central labs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>The SCBDS assay showed a high level of agreement with TBC and improved performance compared to other non\u2010invasive tests. These results demonstrate the potential utility of SCBDS device to aid SIBO diagnosis as a simple and non\u2010invasive tool that merits further clinical validation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14965","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T07:06:59Z","timestamp":1732604819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of a Novel Smart Capsule Bacterial Detection System Device for Diagnosis of Small Intestinal Bacterial Overgrowth"],"prefix":"10.1111","volume":"37","author":[{"given":"Shaoying Nikki","family":"Lee","sequence":"first","affiliation":[{"name":"Biora Therapeutics Inc.  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pejman","family":"Rahimian","sequence":"additional","affiliation":[{"name":"Biora Therapeutics Inc.  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Stork","sequence":"additional","affiliation":[{"name":"Biora Therapeutics Inc.  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-7134","authenticated-orcid":false,"given":"Baharak","family":"Moshiree","sequence":"additional","affiliation":[{"name":"Atrium Health University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Jones","sequence":"additional","affiliation":[{"name":"Biora Therapeutics Inc.  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Chuang","sequence":"additional","affiliation":[{"name":"Biora Therapeutics Inc.  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Wahl","sequence":"additional","affiliation":[{"name":"Biora Therapeutics Inc.  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharat","family":"Singh","sequence":"additional","affiliation":[{"name":"Biora Therapeutics Inc.  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4446-8452","authenticated-orcid":false,"given":"Satish S. C.","family":"Rao","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Augusta University  Augusta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1933313"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000501"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90818-L"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"112","article-title":"Small Intestinal Bacterial Overgrowth: A Comprehensive Review","volume":"3","author":"Dukowicz A. C.","year":"2007","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_10_6_1","first-page":"1","volume-title":"Burnham CAB Clinical Microbiology Procedures Handbook","author":"Pillai D.","year":"2022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.055"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000078"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vgie.2020.11.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.090"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otab045"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31802cbc2f"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0170"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2020.115100"},{"key":"e_1_2_10_15_1","volume-title":"Clinical Microbiology Procedures Handbook","author":"Pillai D. R.","year":"2023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5527"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118548387"},{"key":"e_1_2_10_19_1","unstructured":"P. J.Rahimian S. N.Lee S.Singh et\u00a0al. \u201cA Novel Method for Collecting Microbiome Species \u201d(Poster. Digestive Disease Week San Diego CA May 21\u201324 2022)."}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T04:11:47Z","timestamp":1742098307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/nmo.14965"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14965","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"2024-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14965"}}