{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:33:48Z","timestamp":1769697228548,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303915\/2023\u20104"],"award-info":[{"award-number":["303915\/2023\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304382\/2020\u20105"],"award-info":[{"award-number":["304382\/2020\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["401672\/2023\u20109"],"award-info":[{"award-number":["401672\/2023\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Evaluate the impact of\n \n Spondias mombin<\/jats:italic>\n <\/jats:styled-content>\n L. juice (SM), alone and in combination with\n \n Lactobacillus acidophilus<\/jats:italic>\n <\/jats:styled-content>\n , in an experimental model of intestinal mucositis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Swiss mice were orally administered with saline, SM, or SM combined with\n \n L.\u2009acidophilus<\/jats:italic>\n <\/jats:styled-content>\n NRRL B\u20104495 at 1\u2009\u00d7\u200910\n 9<\/jats:sup>\n colony\u2010forming unit (CFU\/mL) for 15\u2009days before the induction of intestinal mucositis by a single intraperitoneal injection of 5\u2010fluorouracil (5\u2010FU) at 450\u2009mg\/kg. On the 18th day, following euthanasia, tissue samples were collected for histopathological examination. Jejunum tissues were analyzed for MUC\u20102 immunoexpression, concentrations of interleukin\u20101\u2010beta (IL\u20101\u03b2), interleukin 6 (IL\u20106) and tumor necrosis factor (TNF)\u2010\u03b1, and invertase activity.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n 5\u2010FU induced intestinal damage in all intestinal segments, and this damage involved villus blunting, flattened and vacuolated cells, crypt necrosis, inflammatory cell infiltration, and mucosa and submucosal edema compared to the control group. In contrast, SM or SM with\n \n L.\u2009acidophilus<\/jats:italic>\n <\/jats:styled-content>\n prevented these morphological alterations in all intestinal segments (\n p<\/jats:italic>\n \u2009<\u20090.05). Both treatments reduced the intestinal concentration of IL\u20101 beta (\n p<\/jats:italic>\n \u2009<\u20090.05), IL\u20106 (\n p<\/jats:italic>\n \u2009<\u20090.05), and TNF\u2010alpha (\n p<\/jats:italic>\n \u2009<\u20090.05). Notably, the combination of SM and\n \n L.\u2009acidophilus<\/jats:italic>\n <\/jats:styled-content>\n , but not SM alone, prevented the 5\u2010FU\u2010induced decrease in invertase activity and mucin expression (\n p<\/jats:italic>\n \u2009<\u20090.05). Furthermore, SM combined with\n \n L.\u2009acidophilus<\/jats:italic>\n <\/jats:styled-content>\n resulted in an increased population of lactic acid bacteria in feces on the 7th and 18th days. Combining SM with\n \n L.\u2009acidophilus<\/jats:italic>\n <\/jats:styled-content>\n also decreased fecal excretion of \u03b3\u2010Ergostenol and \u03b3\u2010sitosterol.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Inferences<\/jats:title>\n \n SM, alone and combined with\n \n Lactobacillus acidophilus<\/jats:italic>\n <\/jats:styled-content>\n demonstrated significant protective effects against 5\u2010FU\u2010induced intestinal mucositis, reducing inflammatory markers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.14970","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:46:51Z","timestamp":1735631211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of\n Spondias mombin<\/i>\n L. Juice Alone or in Combination With\n Lactobacillus acidophilus<\/i>\n in 5\u2010Fluorouracil\u2010Induced Experimental Intestinal Mucositis"],"prefix":"10.1111","volume":"38","author":[{"given":"Stphannie Jamyla de Ara\u00fajo","family":"Barbosa","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Science, Department of Biophysical and Pharmacology Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maisie Mitchele Barbosa","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in RENORBIO, Department of Biophysical and Pharmacology Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Barbosa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Biophysical and Pharmacology Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaela Alcindo","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Oral Science, Department of Dentistry Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Addison Carvalho Xavier","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry and Molecular Biology, Postgraduate Program in RENORBIO, Department of Biophysical and Pharmacology Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlane Coelho Bernardo","family":"Guerra","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry and Molecular Biology, Postgraduate Program in Pharmaceutical Science, Department of Biophysical and Pharmacology Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimundo Fernandes de Ara\u00fajo","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Postgraduate Program in Functional and Structural Biology UFRN, Department of Morphology Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-4348","authenticated-orcid":false,"given":"Francisco Canind\u00e9","family":"de Sousa Junior","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Science, Department of Pharmaceutical Science Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-0742","authenticated-orcid":false,"given":"Agnes Andrade","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro De Santis","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Drug Quality Control Laboratory (LCQMed), Department of Pharmacy UFRN Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Ayrton Senna Domingos","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Drug Quality Control Laboratory (LCQMed), Department of Pharmacy UFRN Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concei\u00e7\u00e3o S. Martins","family":"Rebou\u00e7as","sequence":"additional","affiliation":[{"name":"N\u00facleo de Microscopia e Processamento de Imagens (NEMPI), Department of Morphology Federal University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerly Anne","family":"de Castro Brito","sequence":"additional","affiliation":[{"name":"N\u00facleo de Microscopia e Processamento de Imagens (NEMPI), Department of Morphology Federal University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Ferreira Carvalho","family":"Leitao","sequence":"additional","affiliation":[{"name":"N\u00facleo de Microscopia e Processamento de Imagens (NEMPI), Department of Morphology Federal University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael Victor Silva","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valkleidson Santos","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-4695","authenticated-orcid":false,"given":"Aurigena Antunes","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Oral Sciences, Postgraduate Program in Pharmaceutical Sciences, Department of Biophysical and Pharmacology Federal University of Rio Grande Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00380.2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-28486-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11671"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.681417"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.544490"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.165"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342079"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081824"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06247-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-013-1100-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2018.10.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2016.03.014"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239392"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-021-09889-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010024"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15051117"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2663-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00847"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000198104"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100503"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15035.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12160"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2020.100845"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf506326t"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054788"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01969-x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2016.02.002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1731459"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2010.531406"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.870399"},{"key":"e_1_2_9_32_1","first-page":"1","article-title":"A Review of Probiotic Ingredient Safety Supporting Monograph Development Conducted by the United States Pharmacopeia (USP)","volume":"14","author":"Boyte M. 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