{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:54:35Z","timestamp":1764510875146,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Anal sensibility is crucial for fecal continence. We aim to investigate anal sensibility in patients diagnosed with different types of ARM, after various types of treatments, and according to the sacral ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospectively, we included 68 ARM patients (7 treated non\u2010surgically and 61 surgically). All underwent anorectal function tests. We measured anal sensibility, the existence of a functional internal anal sphincter (IAS), and sacral ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean anal sensibility was 7.2 (SD 5.2). Normal anal sensibility was present in 40\/60 patients, irrespective of the malformation type. Patients diagnosed with minor types had better anal sensibility than those with major types (5.1 vs. 8.4\u2009mA, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and those treated non\u2010surgically vs. surgically (2.7 vs. 7.7\u2009mA, respectively, <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;\u20090.001). Anal sensibility was significantly better in patients who possessed an IAS than in patients without an IAS (6.4 and 9.2\u2009mA, <jats:italic>p<\/jats:italic>\u2009=\u20090.038). Multivariable regression analysis demonstrated a relationship between anal sensibility and the existence of a functional IAS. Anal sensibility was not associated with the sacral ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Normal anal sensibility can be present in ARM patients diagnosed with all types of ARM after they have been treated with corrective surgery. Anal sensibility was better in those with a functional IAS. This means that the IAS, present in the distal end of the fistula, should be spared as much as possible to preserve anal sensibility. In this way, aiming to maintain the best possible fecal continence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14983","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:38:16Z","timestamp":1735648696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Normal Anal Sensibility in Patients Born With Anorectal Malformations"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-0900","authenticated-orcid":false,"given":"Venla E. C.","family":"den Hollander","sequence":"first","affiliation":[{"name":"Department of Surgery, Anorectal Physiology Laboratory University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Trzpis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Anorectal Physiology Laboratory University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Geriatric Medicine University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-6525","authenticated-orcid":false,"given":"Paul M. A.","family":"Broens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Anorectal Physiology Laboratory University of Groningen, University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Surgery, Division of Pediatric Surgery University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000576"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.055"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01648550"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800730421"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055438"},{"volume-title":"Anatomy, Abdomen and Pelvis, Pudendal Nerve","year":"2022","author":"Kinter K. 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