{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:49:31Z","timestamp":1791172171024,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015170","name":"Department of Industry, Science and Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The shear rheology of ingested fluids influences their pharyngo\u2010esophageal transit during deglutition. Thus, swallowed fluids elicit differing physiological responses due to their shear\u2010thinning profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hydrocolloid fluids, xanthan gum (XG) and sodium carboxymethylcellulose gum (CMC), were compared in 10 healthy adults (mean age 39\u2009years). Manometry swallowing assessments were performed using an 8\u2010French catheter. Swallows were analyzed using the Swallow Gateway web application (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.swallowgateway.com\">www.swallowgateway.com<\/jats:ext-link>). Grouped data were analyzed by a mixed statistical model. The coefficient of determination (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>) assessed the relationship between measures and bolus viscosity (SI units, mPa.s) at shear rates of 1\u20141000\u2009s<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Rheology confirmed that the thickened fluids had similar viscosities at 50\u2009s<jats:sup>\u22121<\/jats:sup> shear rate (XG IDDSI Level\u20101, 2, and 3 respectively, 74.3, 161.2, and 399.6\u2009mPa.s vs. CMC Level\u20101, 2, and 3 respectively 78.0, 176.5, and 429.2\u2009mPa.s). However, at 300\u2009s<jats:sup>\u22121<\/jats:sup> shear, CMC\u2010thickened fluids exhibited approximately double the viscosity (XG Level\u20101, 2, and 3 respectively 19.5, 34.4, and 84.8\u2009mPa.s vs. CMC Level\u20101, 2, and 3 respectively, 41.3, 80.8, and 160.2\u2009mPa.s). In\u00a0vivo swallows of CMC, when compared to XG, showed evidence of greater flow resistance, such as increased intrabolus pressure (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and UES Integrated Relaxation Pressure (UESIRP, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and shorter UES Relaxation Time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and Bolus Presence Time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The apparent fluid viscosity (mPa.s) correlated most significantly with increasing UESIRP (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> 0.69 at 50 s<jats:sup>\u22121<\/jats:sup> and <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> 0.97 at 300\u2009s<jats:sup>\u22121<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fluids with divergent shear viscosities demonstrated differences in pharyngeal function. These physiological responses were linked to the shear viscosity and not the IDDSI level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14988","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:42:39Z","timestamp":1735648959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Bolus Rheology on Physiological Swallowing Parameters Derived by Pharyngeal High\u2010Resolution Manometry Impedance"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7378","authenticated-orcid":false,"given":"T.","family":"Omari","sequence":"first","affiliation":[{"name":"Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Trisco Foods  Carole Park Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schar","sequence":"additional","affiliation":[{"name":"Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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