{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:11:33Z","timestamp":1779185493786,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82105032"],"award-info":[{"award-number":["82105032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable Bowel Syndrome (IBS) is a prevalent condition characterized by dysregulated brain\u2013gut interactions. Despite its widespread impact, the brain mechanism of IBS remains incompletely understood, and there is a lack of objective diagnostic criteria and biomarkers. This study aims to investigate brain network alterations in IBS patients using the functional connectivity strength (FCS) method and to develop a support vector machine (SVM) classifier for distinguishing IBS patients from healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one patients with IBS and thirty age and sex\u2010matched HCs were enrolled in this study and underwent resting\u2010state functional magnetic resonance imaging (fMRI) scans. We applied FCS to assess global brain functional connectivity changes in IBS patients. An SVM\u2010based machine \u2010 learning approach was then used to evaluate whether the altered FCS regions could serve as fMRI\u2010based markers for classifying IBS patients and HCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the HCs, patients with IBS showed significantly increased FCS in the left medial orbitofrontal cortex (mOFC) and decreased FCS in the bilateral cingulate cortex\/precuneus (PCC\/Pcu) and middle cingulate cortex (MCC). The machine\u2010learning model achieved a classification accuracy of 91.9% in differentiating IBS patients from HCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings reveal a unique pattern of FCS alterations in brain areas governing pain regulation and emotional processing in IBS patients. The identified abnormal FCS features have the potential to serve as effective biomarkers for IBS classification. This study may contribute to a deeper understanding of the neural mechanisms of IBS and aid in its diagnosis in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14994","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T18:29:26Z","timestamp":1735928966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Classification of Irritable Bowel Syndrome Using Brain Functional Connectivity Strength and Machine Learning"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-5565","authenticated-orcid":false,"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anorectal Surgery Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"},{"name":"School of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingbo","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Chongqing Hospital of Traditional Chinese Medicine  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Tuina Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(20)30212\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.14"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000700\u20109"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)31548\u20108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201001972\u2010w"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.140806"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.11.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci19010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12695"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.175000"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.053"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.721822"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010015\u20109478\u20101"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.10.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.121"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.851586"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2821832"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.332161"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.08.016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28682"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.05.021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214900110"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1184797"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010023\u201003217\u20103"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1050403"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118649"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100033\u20101335260"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(74)90884\u20108"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.969064"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109759"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5062\u201008.2009"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00545"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.052"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26072"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204471"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa196"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac070"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1401.008"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.05.009"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.049"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2008.03721.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.014"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/2.6.435\u2010a"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108249(199901)45:1<40::aid\u2010art8>3.0.co;2\u2010l"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.09.027"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010019\u20100212\u20107"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.11.006"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0079\u20106123(05)50015\u20103"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010015\u20109558\u20107"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm21079"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.09.011"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.018"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00060.2012"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010020\u201001176\u20105"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0006\u201014.2014"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.079"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00588"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/867924"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25038"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T15:51:03Z","timestamp":1744645863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/nmo.14994"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14994","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"2024-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14994"}}