{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:41:47Z","timestamp":1789753307176,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Colonic manometry (CM) is a diagnostic procedure used to evaluate pediatric patients with refractory constipation, fecal incontinence, Hirschsprung disease, and pediatric intestinal pseudo\u2010obstruction. Pan\u2010colonic high\u2010amplitude propagated contractions (HAPCs), measured by CM, reflect an intact neuromuscular function of the colon. Current guidelines recommend starting CM with fasting recording for 1\u20132\u2009h, but no prior evaluation has determined the diagnostic yield of the fasting phase.<\/jats:p><jats:p>We aimed to determine the utility of the fasting phase during CM studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated CM studies conducted at a tertiary pediatric center (2018\u20132022). Fasting phases of normal CM studies were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In 433 included studies 241 (55.7%) females, median age (9.7\u2009years), the average fasting recording lasted 126\u2009min. A total of 193 (44.6%) studies exhibited fasting HAPCs, with 123 (28.4%) being pan\u2010colonic. The presence of pan\u2010colonic HAPCs was based solely on the fasting phase in 11 (2.5%) studies.<\/jats:p><jats:p>Patients with fasting pan\u2010colonic HAPCs were younger (median age of 6.9 vs. 9.8\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001) and had a higher rate of postprandial HAPCs (69.1% vs. 25.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><jats:p>Most fasting pan\u2010colonic HAPCs presented during the first 60\u2009min (94\/123, 76.4%). All studies demonstrated HAPCs after stimulation with bisacodyl.<\/jats:p><jats:p>In analyzing just the initial 30\u2009min of fasting on CM, only 2 (0.5%) studies would have been misclassified as abnormal, with no bisacodyl administration in these studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Shortening the fasting phase minimally affects next\u2010day CM results and could reduce patient inconvenience, hospital\u2010related costs, and potential side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14998","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T06:48:17Z","timestamp":1736491697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Utility of Monitoring Fasting Phase During Pediatric Colonic Manometry Studies"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-2807","authenticated-orcid":false,"given":"Lev","family":"Dorfman","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"El\u2010Chammas","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahana","family":"Khanna","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fei","sequence":"additional","affiliation":[{"name":"Biostatistics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kaul","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v11.i5.385"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000266"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-15229-0_12"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i18.2675"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9745-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12944"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003429"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14759"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-022-00849-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12876"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70120-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13851"},{"issue":"4","key":"e_1_2_10_15_1","first-page":"398","article-title":"Bisacodyl and High\u2010Amplitude\u2010Propagating Colonic Contractions in Children","volume":"27","author":"Hamid S.","year":"1998","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237305"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90539-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831043"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13239"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14528"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T15:51:12Z","timestamp":1744645872000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/nmo.14998"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14998","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,9]]},"assertion":[{"value":"2024-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14998"}}