{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:43Z","timestamp":1753879303755,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Disorders of gut\u2013brain interactions (DGBI) affect more women, and marital quality may have been a factor that explains clinical manifestations of DGBI\u2014however, the mechanism is unclear. This study aimed to elucidate supported relationships between DGBI with marital quality and clinical attributes in married Malay women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study involved married Malay women with functional dyspepsia (FD), irritable bowel syndrome (IBS), and FD\u2010IBS overlap per Rome IV criteria. Multivariate analysis of variance (MANOVA) and Pearson correlation analysis were performed to determine the association between DGBI, marital quality, and clinical attributes of catastrophizing, psychological dysfunction, and quality of life. Path analysis models were developed, tested, and fitted to elucidate relationships that satisfied significance testing and fit indices (termed supported relationship).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Of 1130 screened participants, 513 were analyzed. The prevalence of FD, IBS, and FD\u2010IBS overlap was 33.9% (<jats:italic>n<\/jats:italic>\u2009=\u2009174), 29.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009151), and 36.6% (<jats:italic>n<\/jats:italic>\u2009=\u2009188), respectively. Of 17 variables in MANOVA, significant differences in variables were observed for FD vs. FD\u2010IBS overlap (10), IBS versus FD (10), and IBS versus FD\u2010IBS overlap (5). Pearson correlation matrices found significant correlations for 15 of 17 variables. After testing and fitting, the third path model (Model 3) was\u00a0deemed the final model. Model 3 suggested that relationships between DGBI and marital and clinical attributes were complex and bidirectional. The number of supported relationships were 50, 43, and 39 for FD\u2010IBS overlap, FD, and IBS, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Relationships between DGBI, marital quality, and clinical attributes among married Malay women are complex and bidirectional.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.15000","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T07:14:55Z","timestamp":1736493295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complex and Bidirectional Interplay Between Marital Quality, Catastrophizing, Psychological Dysfunction, and Quality of Life in Married Malay Women With Disorder of Gut\u2013Brain Interactions"],"prefix":"10.1111","volume":"37","author":[{"given":"Nurhazwani","family":"Hamid","sequence":"first","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Cheng","family":"Kueh","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosediani","family":"Muhamad","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zalina","family":"Zahari","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universiti Sultan Zainal Abidin  Besut Terengganu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-9829","authenticated-orcid":false,"given":"Miranda A. L.","family":"van Tilburg","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina\u2010Chapel Hill  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olafur S.","family":"Palsson","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina\u2010Chapel Hill  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-7602","authenticated-orcid":false,"given":"William E.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina\u2010Chapel Hill  North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng Feei","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Health, Science and Society School University of the West of England  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-7563","authenticated-orcid":false,"given":"Nashrulhaq","family":"Tagiling","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-7717","authenticated-orcid":false,"given":"Yeong Yeh","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.017"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18082"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18064"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00102-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.05.042"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14040393"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-84"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0031859"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10896-021-00262-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/157340"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781412961288"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14602"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.014"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06943.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-0606.1995.tb00163.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/JPBS.JPBS_265_19"},{"volume-title":"Marriage in the 90s: A Nationwide Random Phone Survey","year":"1997","author":"Stanley S. 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