{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:35Z","timestamp":1753878695694,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton pump inhibitors (PPI) for gastroesophageal reflux disease (GERD) are associated with a high failure rate. Our uncontrolled feasibility study aimed determining the effect of a transcutaneous electrical stimulation system (TESS) on GERD symptoms and acid exposure time (AET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Recruited patients with heartburn and regurgitation. During the first phase (one\u2010week, run\u2010in period, off\u2010PPI's), patients completed symptom diaries and demographic questionnaires. Thereafter, all patients underwent gastroscopy with subsequent placement of a wireless esophageal pH capsule, off\u2010PPI. Based on pH analysis in the first 24\u2009h, only those with increased AET (percent total time pH &lt;\u20094 above 6%) continued to the next phase. During that phase, patients were treated for up to 3\u2009weeks with TESS and documented their symptoms. The Primary endpoint was the magnitude of reduction in GERD\u2010related symptoms. The secondary endpoints were the magnitude of reduction of AET and DeMeester score, as compared with their baseline values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Included 31 patients and of those, 26 patients (42% females, aged 49\u2009\u00b1\u200915\u2009years, mean BMI 25\u2009\u00b1\u20093\u2009kg\/m<jats:sup>2<\/jats:sup>) completed the first two phases of the study.<\/jats:p><jats:p>At baseline, mean number of daily heartburn and regurgitation episodes was 2.55\u2009\u00b1\u20091.79 and 1.40\u2009\u00b1\u20091.73, respectively. Following TESS, mean number of daily heartburn and regurgitation episodes dropped to 0.77\u2009\u00b1\u20090.75 and 0.36\u2009\u00b1\u20090.8, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At base line, mean AET and DeMeester score were 12.4\u2009\u00b1\u20095.6 and 32.1\u2009\u00b1\u200912.7, respectively. Following TESS mean AET dropped to 6.0\u2009\u00b1\u20093.5 and DeMeester score dropped to 16.2\u2009\u00b1\u20098.2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TESS is effective in reducing both symptoms and esophageal AET in GERD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.15002","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:49:24Z","timestamp":1737629364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of the Transcutaneous Electrical Stimulation System on Heartburn, Regurgitation and Esophageal Acid Exposure in <scp>GERD<\/scp> Patients\u2014An Uncontrolled Feasibility Study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-2849","authenticated-orcid":false,"given":"Ram","family":"Dickman","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Rabin Medical Center, Beilinson Campus  Petah Tikva Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Brun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rambam Health Care Campus, Faculty of Medicine Technion Institute  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Levy","sequence":"additional","affiliation":[{"name":"Statistics Education Unit The Academic College of Tel Aviv\u2010Yafo  Tel Aviv 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