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Accumulating data also indicate that alterations in the gut can modulate Alzheimer's disease pathology, highlighting the need to better understand the link between gastrointestinal abnormalities and neurodegeneration in the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To disentangle the pathophysiology of gastrointestinal dysfunction in Alzheimer's disease, we conducted a detailed pathological characterization of the gastrointestinal tract of 5xFAD mice by performing histological analyses, gene expression studies, immunofluorescence labeling and gut function assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 5xFAD mice have elevated levels of intestinal amyloid precursor protein and accumulate amyloid\u2010\u03b2 in enteric neurons. Histopathology revealed that this is associated with mild intestinal inflammation and fibrosis and accompanied by increased expression of proinflammatory cytokines. While overall enteric nervous system composition and organization appeared unaffected, 5xFAD mice have faster gastrointestinal transit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that amyloid\u2010\u03b2 accumulation in enteric neurons is associated with low\u2010grade intestinal inflammation and altered motility and suggest that peripheral pathology may cause gastrointestinal dysfunction in Alzheimer's disease patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.15016","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:48:49Z","timestamp":1741754929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gastrointestinal Dysfunction and Low\u2010Grade Inflammation Associate With Enteric Neuronal Amyloid\u2010\u03b2 in a Model for Amyloid 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