{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:07:50Z","timestamp":1780337270886,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prevalence of opioid use and its impact on healthcare outcomes among patients with Rome IV functional dyspepsia (FD) has not been reported in real\u2010world clinical practice in the United Kingdom (UK). The primary aim of this study was to study the prevalence of opioid intake among outpatients diagnosed with Rome IV FD. Secondary aims were to determine (A) the differences in phenotype and healthcare resource utilization between patients who consumed opioids versus non\u2010users, and (B) whether a combination of opioid cessation and a neuromodulator prescription could improve gastrointestinal (GI) symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Data were collected from consecutive patients diagnosed with FD according to the Rome IV clinical criteria in a single tertiary care neurogastroenterology outpatient clinic in the UK between January 2016 and December 2021. Patients who consumed opioids were provided with opioid cessation advice and prescribed a neuromodulator (the intervention).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifty\u2010six patients were diagnosed with FD and 48 (31%) were taking opioids. In a multivariate logistic regression model (OR, [95% CI]), older age (1.03 [1.004\u20131.059], <jats:italic>p<\/jats:italic>\u2009=\u20090.03), depression and\/or anxiety (4.2 [1.4\u201312.5], <jats:italic>p<\/jats:italic>\u2009=\u20090.01), and chronic pain (4.0 [1.8\u20138.9], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were independently associated with opioid consumption at baseline. At least 44% of patients adhered to opioid cessation advice and, among these persons, 29% reported symptom improvement in response to a neuromodulator. The intervention had a number needed to treat of 5.7 to achieve an improvement in clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Opioid intake in FD is independently associated with older age, depression and\/or anxiety, and chronic pain. Encouraging opioid cessation may be an important strategy in the management of FD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.15019","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:19:12Z","timestamp":1741713552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Characteristics and Outcomes of Patients With Rome <scp>IV<\/scp> Functional Dyspepsia Who Consume Opioids: A Real\u2010World Study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-6470","authenticated-orcid":false,"given":"Mohsin F.","family":"Butt","sequence":"first","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Isherwood","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilly","family":"Lewis\u2010Lawson","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9267-9471","authenticated-orcid":false,"given":"Caterina","family":"Sbarigia","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-5039","authenticated-orcid":false,"given":"Christian","family":"Lambiase","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1559-7893","authenticated-orcid":false,"given":"Razan N. M.","family":"Aburumman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-2569","authenticated-orcid":false,"given":"Arkadeep","family":"Dhali","sequence":"additional","affiliation":[{"name":"Academic Department of Gastroenterology Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Bush","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2555-2250","authenticated-orcid":false,"given":"Tim","family":"Card","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-4684","authenticated-orcid":false,"given":"Maura","family":"Corsetti","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001052"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.0217"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2021.2219"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01205-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14574"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.596467"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327737"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14503"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30003-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501505"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.279"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro\u20102022\u2010102268"},{"key":"e_1_2_10_16_1","unstructured":"CDC \u201cPocket Guide: Tapering Opioids for Chronic Pain: CDC \u201d (2016) https:\/\/www.cdc.gov\/drugoverdose\/pdf\/clinical_pocket_guide_tapering\u2010a.pdf."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00648"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.71"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012509.pub2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.02.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010664"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.202100239"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2011.03.006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12061"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.154"}],"container-title":["Neurogastroenterology &amp; 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