{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:37Z","timestamp":1753878697939,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with chronic disorders of the gastrointestinal (GI) system, integral health is disturbed in all dimensions: physical, mental, quality of life, participation, meaningfulness, and daily functioning. In this group, three large subgroups are distinguished: Inflammatory Bowel Diseases (IBD), Hepato\u2010Pancreatico\u2010Biliary diseases (HPB), and NeuroGastroenterology and Motility (NGM) disorders.<\/jats:p><jats:p>Our aim was to compare integral health status between these three subgroups. For the NGM group, we focused on patients with documented motility disorders, not on patients with functional GI\u2010disorders. We hypothesized that the NGM group will have lower scores for integral health status compared to the IBD and HPB groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, observational, questionnaire study was performed in patients with chronic GI\u2010system disorders (IBD, HPB, and NGM) attending the Maastricht University Medical Center outpatient department. Validated questionnaires and patient file data were used to quantify six health dimensions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Data from 416 patients were collected. In all domains, apart from meaningfulness, the NGM group (<jats:italic>n<\/jats:italic>\u2009=\u200993) had significantly (0.001\u2009\u2264\u2009<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.033) lower scores compared to the IBD (<jats:italic>n<\/jats:italic>\u2009=\u2009174) and HPB (<jats:italic>n<\/jats:italic>\u2009=\u2009149) groups. From the NGM group, 66% were malnourished, had symptoms of depression (36%) and anxiety (19%), and work participation was lowest (32%). Correlations between intra\u2010 and interdimensional parameters were moderate to strong apart from meaningfulness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Compared to patients with chronic IBD and HPB disorders, patients with NGM disorders have significantly lower scores in five of six dimensions of health: physical and mental well\u2010being, quality of life, daily functioning, and participation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.15021","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:52:51Z","timestamp":1739857971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Health Status in Patients With Chronic Disorders of the Gastrointestinal System Disease\u2010Specific? 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M.","family":"Lemlijn\u2010Slenter","sequence":"first","affiliation":[{"name":"Department of Gastroenterology \u2013 Hepatology, School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Department of Social Medicine, Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Social Medical Affairs (SMZ) The Dutch Social Security Institute: The Institute for Employee Benefits Schemes (UWV)  Amsterdam the Netherlands"},{"name":"Department of Research Academic Knowledge Center Work and Health South\u2010East Netherlands (AKAG\u2010ZON)  Heerlen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-7209","authenticated-orcid":false,"given":"Luuk P.","family":"van Iperen","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Research Academic Knowledge Center Work and Health South\u2010East Netherlands (AKAG\u2010ZON)  Heerlen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8206-9824","authenticated-orcid":false,"given":"Karolina A. 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