{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:38Z","timestamp":1753879238269,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009800","name":"Stiftelsen Professor Nanna Svartz Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009800","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether uncomplicated diverticulosis gives rise to symptoms is controversial. Diary\u2010based studies of abdominal pain and stool habits in general populations are scarce, and we therefore investigated symptom patterns in diverticulosis from prospectively collected symptom diaries in a random sample of the general population who completed a research colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the Swedish population\u2010based colonoscopy (PopCol) study, 745 individuals from the general population underwent a colonoscopy of which 130 had diverticulosis, and none had diverticulitis. Seven\u2010day symptom diaries were completed by 258 participants (age 54, women 64%) of which 50 had diverticulosis. The frequency and location of abdominal pain, bowel habit and other gastrointestinal symptoms were compared between individuals with and without diverticulosis using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Diverticulosis was not associated with abdominal pain (OR 1.24, CI 0.61\u20132.55) or left lower quadrant (LLQ) abdominal pain (OR 1.59, CI 0.73\u20133.49). Pain duration and severity were not associated with diverticulosis. When individuals with diverticulosis had pain, it was more often in the LLQ (OR 2.45, CI 1.02\u20135.86) compared with those without diverticulosis. Diverticulosis was not linked to altered bowel habits. Irritable bowel syndrome prevalence was 16% in the diverticulosis group and 19% in the non\u2010diverticulosis group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Participants with diverticulosis did not report more abdominal pain or more LLQ abdominal pain than participants without diverticulosis. Bowel habit was not abnormal in diverticulosis. Our results do not support that uncomplicated diverticulosis cause symptoms in individuals without a history of acute diverticulitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70000","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:13:37Z","timestamp":1739855617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncomplicated Diverticulosis Is Not Associated With Abdominal Pain or Abnormal Bowel Habit\u2014A Population\u2010Based Swedish Cohort Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Bjarki T.","family":"Alexandersson","sequence":"first","affiliation":[{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-4938","authenticated-orcid":false,"given":"Michael P.","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Macquarie University  North Ryde Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte R. H.","family":"Hedin","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Gastroenterology, Dermatovenereology and Rheumatology Centre for Digestive Health, Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellionore","family":"J\u00e4rbrink\u2010Sehgal","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Gastroenterology, Hepatology and Nutrition Department UT MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences (HMV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-3092","authenticated-orcid":false,"given":"Nicholas J.","family":"Talley","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Agreus","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Andreasson","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Macquarie University  North Ryde Australia"},{"name":"Department of Health, Medicine and Caring Sciences (HMV) Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Psychology Stockholm University  Stockholm Sweden"},{"name":"Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-5468","authenticated-orcid":false,"given":"Peter T.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000094"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.04.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.621"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12152"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100153\u20105"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737\u2010200309000\u201000011"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335721"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.06.014"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001296"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000024"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737\u2010199805000\u201000011"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.6.818"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.194"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.048"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002236"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14304"}],"container-title":["Neurogastroenterology &amp; 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