{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:58:19Z","timestamp":1780491499539,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Studies demonstrate an overlap of constipation with gastroparesis and functional dyspepsia, but the impact of treatments that target constipation on improving upper gastrointestinal (UGI) symptoms is unexplored. We quantified the effects of constipation medication therapies on UGI and constipation symptom severity in subjects presenting with symptoms of gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six subjects with symptoms of gastroparesis underwent concurrent wireless motility capsule and gastric emptying scintigraphy and were recommended to receive either a new medication therapy for constipation or a change in constipation therapy based on investigator interpretation of test results. Gastroparesis Cardinal Symptom Index (GCSI), upper abdominal pain, and constipation scores were compared between baseline and 6\u2009months. Data were compared between delayed or non\u2010delayed gastric emptying and the presence or absence of slow colonic transit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Subjects with slow colonic transit had improvements in GCSI (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) and constipation scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) after treatment with a new or changed constipation medication, with the delayed emptying subgroup driving GCSI improvements (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). Reductions in nausea\/vomiting (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) and early satiety\/fullness subscores (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) with trends to improved bloating\/distention subscores (<jats:italic>p<\/jats:italic>\u2009=\u20090.06) were observed in this subgroup, but upper abdominal pain was unchanged. Subjects with normal colonic transit showed no improvement in GCSI scores regardless of gastric emptying status (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Identifying and treating delayed colonic transit in gastroparetic (delayed gastric emptying) subjects improves global UGI symptoms as well as selected individual symptoms. Evaluation of whole gut motility as well as recognizing and managing extragastric delay may promote improved outcomes in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT02022826<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70013","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:02:13Z","timestamp":1741726933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Constipation Therapies on Severity of Gastroparesis and Constipation Symptoms in Relation to Gastric and Colonic Transit"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-3383","authenticated-orcid":false,"given":"Brian C.","family":"Surjanhata","sequence":"first","affiliation":[{"name":"Center for Neurointestinal Health, Gastroenterology Unit Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-7134","authenticated-orcid":false,"given":"Baharak","family":"Moshiree","sequence":"additional","affiliation":[{"name":"Atrium Health Wake Forest Baptist Morehead Medical Plaza  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of Michigan Health System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-8049","authenticated-orcid":false,"given":"Richard W.","family":"McCallum","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology Texas Tech University  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-7269","authenticated-orcid":false,"given":"Irene","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology Texas Tech University  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3498-6897","authenticated-orcid":false,"given":"Linda A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Schulman","sequence":"additional","affiliation":[{"name":"Florida Digestive Health Associates  Largo Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-3255","authenticated-orcid":false,"given":"John M.","family":"Wo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-4891","authenticated-orcid":false,"given":"Henry P.","family":"Parkman","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braden","family":"Kuo","sequence":"additional","affiliation":[{"name":"Center for Neurointestinal Health, Gastroenterology Unit Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Hasler","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Mayo Clinic Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4446-8452","authenticated-orcid":false,"given":"Satish S. 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