{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:12:39Z","timestamp":1787807559649,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Disorders of gut\u2010brain interaction (DGBI) are a heterogeneous group of chronic conditions without a known organic etiology, with a significant socio\u2010economic impact. In clinical practice, challenges remain in accurately assessing DGBI symptoms. Accurate interpretation and communication of the symptom pattern are imperative for a correct diagnosis. Hence, our group recently developed a Rome criteria\u2010based Waiting Room Questionnaire (WRQ) with pictograms for visual support to improve symptom identification. This cross\u2010sectional study aims to validate the WRQ for symptom assessment and DGBI diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a tertiary care multicentric study, 245 ambulatory patients (71% female, 41\u2009\u00b1\u200919.4\u2009years old) completed the WRQ. The clarity and added value were recorded by the patients. The concordance between diagnosis based on the WRQ most bothersome symptom and the expert clinician's diagnosis were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the expert opinion of clinicians, 53 patients were primarily diagnosed with gastro\u2010esophageal reflux disease (GERD), 66 with postprandial distress syndrome (PDS), 36 with epigastric pain syndrome (EPS), 57 with irritable bowel syndrome (IBS) and 26 with chronic nausea\/vomiting syndrome (CNVS). Pictograms entailed an added value according to 88% of the patients, and 95% of the patients understood all questions. Overall, patients' answers on the WRQ were highly reliable. Inter\u2010rater agreement was substantial (Cohen's kappa\u2009=\u20090.72) with an overall concordance of 78% between expert opinion and the most bothersome symptom reported on the WRQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The WRQ is a comprehensive and reliable tool facilitating the diagnosis of patients with DGBI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70019","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:41:19Z","timestamp":1744692079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Waiting Room Questionnaire, a Patient\u2010Reported Outcome Instrument Including Pictograms for Facilitating the Diagnosis of Functional Gastrointestinal Disorders"],"prefix":"10.1111","volume":"37","author":[{"given":"Nick","family":"Goelen","sequence":"first","affiliation":[{"name":"Gastroenterology, TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Scheepers","sequence":"additional","affiliation":[{"name":"Gastroenterology, TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Gastroenterology, TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieselot","family":"Holvoet","sequence":"additional","affiliation":[{"name":"Gastroenterology UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Medical Research Consultant  Chaumont\u2010Gistoux Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Arts","sequence":"additional","affiliation":[{"name":"Gastroenterology UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Boeckxstaens","sequence":"additional","affiliation":[{"name":"Gastroenterology, TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Caenepeel","sequence":"additional","affiliation":[{"name":"Gastroenterology UZ Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Gijsen","sequence":"additional","affiliation":[{"name":"Gastroenterology Mariaziekenhuis Noord\u2010Limburg  Pelt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Latour","sequence":"additional","affiliation":[{"name":"Gastroenterology CHU de Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Lef\u00e8bvre","sequence":"additional","affiliation":[{"name":"Gastroenterology CHR de Namur  Namur Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Neirynck","sequence":"additional","affiliation":[{"name":"Gastroenterology Regional Hospital Heilig Hart  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Piessevaux","sequence":"additional","affiliation":[{"name":"Gastroenterology Cliniques Universitaires St. Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"Gastroenterology, TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Vergauwe","sequence":"additional","affiliation":[{"name":"Gastroenterology AZ Groeninge  Kortrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Gastroenterology, TARGID KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cRome IV Diagnostic Criteria for FGIDs \u201dhttps:\/\/theromefoundation.org\/rome\u2010iv\/rome\u2010iv\u2010criteria\/."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000306"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12855"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.053355"},{"key":"e_1_2_11_10_1","unstructured":"D. A.Drossman \u201cRome III Diagnostic Criteria for Functional Gastrointestinal Disorders \u201d2006."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.037"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.048"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:46:49Z","timestamp":1749790009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/nmo.70019"],"URL":"https:\/\/doi.org\/10.1111\/nmo.70019","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"2024-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70019"}}