{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:40Z","timestamp":1753879240077,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy and safety of intrarectal botulinum toxin A (BoNT\/A) injections in patients with urge fecal incontinence (FI) were evidenced in a large, multicenter, randomized, placebo\u2010controlled study (FI\u2010TOXIN). The aims of the present study were to evaluate the long\u2010term efficacy and safety of intrarectal BoNT\/A injections in a real\u2010world setting in patients who participated in the FI\u2010TOXIN study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data collected from patients who had previously participated in the FI\u2010TOXIN study in 8 French centers from November 2015 to November 2020 were retrospectively analyzed. Given the transient effect of BoNT\/A, patients who had received the first injection in the FI\u2010TOXIN study could be re\u2010injected if symptoms recurred. Information on re\u2010injections, satisfaction of patients, severity of FI symptoms, adverse effects, and the switch to another treatment was retrospectively collected from medical charts between M6 (end of the double\u2010blind phase) and M54 of the inclusion in the FI\u2010TOXIN study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Of the 191 patients in the initial FI\u2010TOXIN cohort, 147 (77.0%) were included at M6. Between M6 and M54, 114 of these patients received 233 injections (68 first injections, 165 re\u2010injections). Satisfaction information was available for 70 patients, of whom 43\/70 (61.4%) were satisfied with all their injections. The treatment failed in 52\/147 (35.4%) of the patients, with rejections of the treatment by patients due to insufficient perceived efficacy (34 patients), adverse effects or poor tolerance (11 patients), or switch to a surgical treatment (23 patients). Nonsevere adverse events were recorded after 45\/233 (19.3%) injections. The two severe adverse events (cervical cancer and psychiatric hospitalization) were unrelated to the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intrarectal injections of BoNT\/A displayed moderate long\u2010term efficacy without major adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70025","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:32:16Z","timestamp":1744007536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrarectal Injections of Botulinum Toxin for the Treatment of Urge Fecal Incontinence: Long\u2010Term Results of an <scp>FI<\/scp>\u2010Toxin Cohort Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Charlotte","family":"Desprez","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Rouen Normandie, INSERM, ADEN UMR1073, CHU Rouen, CIC\u2010CRB 1404 Department of Digestive Physiology  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6301","authenticated-orcid":false,"given":"Charl\u00e8ne","family":"Brochard","sequence":"additional","affiliation":[{"name":"Department of Diseases of the Digestive Tract, Functional Digestive Explorations Division CHRU Pontchaillou, CIC1414, Universit\u00e9 de Rennes 1, Rennes &amp; INSERM U1235, Universit\u00e9 de Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Vitton","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology H\u00f4pital Nord, Assistance\u2010Publique H\u00f4pitaux de Marseille, Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Etienney","sequence":"additional","affiliation":[{"name":"Department of Coloproctology Groupe Hospitalier Diaconesses Croix Saint\u2010Simon  Paris 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Herriot Hospital  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Queralto","sequence":"additional","affiliation":[{"name":"Coloproctology Unit Clinique Des C\u00e8dres  Cornebarrieu France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9155","authenticated-orcid":false,"given":"Guillaume","family":"Gourcerol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rouen Normandie, INSERM, ADEN UMR1073, CHU Rouen, CIC\u2010CRB 1404 Department of Digestive Physiology  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Siproudhis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Inphy CIC1414 CHU Rennes, Universit\u00e9 de Rennes 1  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Damon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de 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