{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:06:34Z","timestamp":1784660794562,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dysmotility is common in acute pancreatitis (AP) and may be evaluated using radiopaque markers and imaging. We present a simple CT\u2010based approach, which was employed in hospitalized patients with AP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a secondary analysis of a randomized, controlled trial conducted at four Danish centers. Patients admitted with AP and systemic inflammatory response syndrome were randomized to receive 5\u2009days of intravenous methylnaltrexone or placebo (lactated ringer) added to standard management. Self\u2010reported stool frequency was documented daily. Patients ingested a capsule containing 10 radiopaque markers on Day 3. A subsequent CT scan on Day 5 was used to identify the location of retained markers for the calculation of gastrointestinal transit, and colonic dimensions (diameters and cross\u2010sectional areas) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 47 patients were included. Patients receiving methylnaltrexone less often had laxative treatment (57% vs. 88%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) compared with placebo. Transit times were similar between the methylnaltrexone and the placebo groups (difference, \u22124\u2009h (95% CI, \u221216 to 8), <jats:italic>p<\/jats:italic>\u2009=\u20090.53). Marker retention scores, colon diameters, and colon cross\u2010sectional areas did not differ between treatment groups (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Transit times (\u03c1\u2009=\u2009\u22120.53; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), marker retention scores (\u03c1\u2009=\u2009\u22120.42; <jats:italic>p<\/jats:italic>\u2009=\u20090.004), diameter (\u03c1\u2009=\u2009\u22120.43; <jats:italic>p<\/jats:italic>\u2009=\u20090.003), and cross\u2010sectional areas (\u03c1\u2009=\u2009\u22120.36; <jats:italic>p<\/jats:italic>\u2009=\u20090.01) of the descending colon were negatively correlated with self\u2010reported stool frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our CT\u2010based method was feasible in hospitalized patients with AP. Methylnaltrexone did not change gastrointestinal transit compared with placebo. However, laxative therapy was more frequent with the placebo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70027","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T05:55:44Z","timestamp":1742882144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal Transit Time Assessed Using a <scp>CT<\/scp>\u2010Based Radiopaque Marker Method in Patients With Acute Pancreatitis During Methylnaltrexone Treatment"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-1487","authenticated-orcid":false,"given":"Cecilie Siggaard","family":"Knoph","sequence":"first","affiliation":[{"name":"Mech\u2010Sense and Centre for Pancreatic Diseases, Department of Gastroenterology &amp; Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Svenstrup","family":"Hesthaven","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense and Centre for Pancreatic Diseases, Department of Gastroenterology &amp; Hepatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias Ellgaard","family":"Cook","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense and Centre for Pancreatic Diseases, Department of Gastroenterology &amp; Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdan","family":"Novovic","sequence":"additional","affiliation":[{"name":"Pancreatitis Centre East, Gastro Unit Copenhagen University Hospital Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Berner","family":"Hansen","sequence":"additional","affiliation":[{"name":"Digestive Disease Centre K, Bispebjerg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Bau","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Odense Pancreas Centre, HPB Section, Department of Surgery Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv Bjerre Juul","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Digestive Disease Centre K, Bispebjerg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Maria","family":"H\u00f8gsberg","sequence":"additional","affiliation":[{"name":"Odense Pancreas Centre, HPB Section, Department of Surgery Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Salomon","sequence":"additional","affiliation":[{"name":"Department of Surgery A4 Odense University Hospital  Svendborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Thorlacius\u2010Ussing","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery A Aalborg Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-7430","authenticated-orcid":false,"given":"Esben Bolvig","family":"Mark","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense and Centre for Pancreatic Diseases, Department of Gastroenterology &amp; 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