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This study aimed to compare the neural correlates of anxiety inindividuals with CD relative to HC, using resting\u2010state fMRI data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants filled in the State\u2013Trait Anxiety Inventory (STAI), a validated tool for measuring anxiety, and underwent an MRI acquisition, including both structural and functional sequences, to identify brain regions associated with anxiety scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients with CD and eighteen HC matched for age, education, and sex participated in the study. No significant group differences emerged in the STAI scores. However, resting\u2010state fMRI analysis revealed distinct patterns of functional connectivity associated with anxiety scores for the two study groups. Among CD group, greater STAI scores correlated with increased functional connectivity, whereas, in HC, they correlated with decreased functional connectivity. Significant clusters were found in brain regions belonging to specific resting\u2010state networks (RSNs): (a) Posterior Cingulate Cortex (PCC, within the Default Mode Network), (b) left Middle Frontal Gyrus (within the Left Fronto\u2010Parietal Network), and (c) PCC and right Superior Temporal Gyrus (within the Dorsal Attention Network).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The differential association between functional connectivity and STAI scores observed for CD and HC participants was located in areas within self\u2010referential (Default Mode Network) and cognitive (Left Fronto\u2010Parietal Network and Dorsal Attention Network) RSNs. Our findings suggest that maladaptive\/dysfunctional processing of negative emotions and visceral sensitivity may occur in patients with CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70029","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T06:00:07Z","timestamp":1742882407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>A Heavy Feeling in the Stomach<\/i>: Neural Correlates of Anxiety in Crohn's Disease"],"prefix":"10.1111","volume":"37","author":[{"given":"Silvia","family":"Tempia Valenta","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"},{"name":"Doctoral Program of Global Health, Humanitarian Aid and Disaster Medicine Vrije Universiteit Brussel  Bruxelles Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences IRCCS Sant'Orsola\u2010Malpighi Hospital, University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Benuzzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Rizzello","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences IRCCS Sant'Orsola\u2010Malpighi Hospital, University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gionchetti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences IRCCS Sant'Orsola\u2010Malpighi Hospital, University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"De Ronchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rita","family":"Atti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3156-9967","authenticated-orcid":false,"given":"Alessandro","family":"Agostini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Surgical Sciences IRCCS Sant'Orsola\u2010Malpighi Hospital, University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Filippini","sequence":"additional","affiliation":[{"name":"IRCCS San Camillo Hospital  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318484"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.579"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60026-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12395"},{"key":"e_1_2_12_7_1","first-page":"661","article-title":"Crohn's Disease: Diagnosis and Management","volume":"98","author":"Veauthier B.","year":"2018","journal-title":"American Family Physician"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21417"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001954"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02586-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20511"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.142"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/21642850.2021.2007098"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1458918","article-title":"Role of Stress and Early\u2010Life Stress in the Pathogeny of Inflammatory Bowel Disease","volume":"18","author":"Bonaz B.","year":"2024","journal-title":"Frontiers in Neuroscience"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwy038"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy235"},{"key":"e_1_2_12_17_1","article-title":"Beyond Depression and Anxiety in IBD: Forging a Path Towards Emotional Healing","author":"Chester M. 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