{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:04:03Z","timestamp":1771542243822,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dysphagia is prevalent in individuals with Huntington's disease (HD), yet the underlying mechanisms of dysphagia remain unknown. We profiled swallowing safety and physiology in individuals with HD using the validated Penetration\u2010Aspiration Scale (PAS) and the Modified Barium Swallow Impairment Profile (MBSImP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 40 adults with HD who underwent videofluoroscopic swallow studies (VFSS) between 2018 and 2024 at Vanderbilt University Medical Center. Trained raters extracted demographics, disease characteristics (duration, United Huntington Disease Rating Scale [UHDRS] Motor Component Total scores, cytosine, adenine, guanine [CAG] repeats), and worst PAS scores from Epic. Two MBSImP\u2010certified clinicians performed duplicate, independent, blinded ratings to obtain overall impairment and severity ratings. Inter\u2010 and intra\u2010rater reliability, descriptive statistics, and Spearman's Rho correlations were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Swallowing safety profiles observed were 65% safe, 7.5% penetration, and 27.5% aspiration. 81% of aspirators did so silently. Relationships between PAS scores and disease duration (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.336, <jats:italic>p<\/jats:italic>\u2009=\u20090.036) and PAS scores and UHDRS motor scores (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.382, <jats:italic>p<\/jats:italic>\u2009=\u20090.020) were noted. 85% of MBSImP oral phase scores and 97.5% of pharyngeal phase scores had none\u2010to\u2010mild severity, while 15% and 2.5%, respectively, showed moderate severity. No significant correlations were observed between MBSImP scores, demographics, or disease characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>Individuals with HD exhibited greater impairments in swallowing efficiency than in safety, with the oral phase more affected than the pharyngeal. Relationships between swallowing safety and disease severity characteristics in HD suggest these metrics may serve as indicators of swallowing safety impairments, and that further assessment is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70035","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T10:59:14Z","timestamp":1743073154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Profiling Swallowing Safety and Physiology in People With Huntington's Disease"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-2469","authenticated-orcid":false,"given":"Claudia","family":"Raines","sequence":"first","affiliation":[{"name":"Department of Hearing and Speech Sciences Vanderbilt University  Nashville Tennessee USA"},{"name":"Innovative Research in Aerodigestive Disorders Laboratory Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makenna","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Sciences Vanderbilt University  Nashville Tennessee USA"},{"name":"Innovative Research in Aerodigestive Disorders Laboratory Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara","family":"Donohue","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Sciences Vanderbilt University  Nashville Tennessee USA"},{"name":"Innovative Research in Aerodigestive Disorders Laboratory Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)60111\u20101"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201072250\u2010w"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009595"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1293"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010016\u20101273\u2010y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010022\u20101743\u20106"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010010\u20109302\u20104"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010020\u201004265\u20100"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02493441"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010015\u20109631\u20104"},{"key":"e_1_2_12_13_1","unstructured":"\u201cMBS Measurement Tool for Swallow Impairment\u2014MBSImp: Establishing a Standard \u2013 PMC \u201dOctober 22 2024 https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4217120\/."},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1044\/persp2.SIG13.129"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2014.02.003"},{"key":"e_1_2_12_16_1","unstructured":"\u201cEpic Systems \u201d2019 https:\/\/www.epic.com\/about."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010016\u20109758\u2010y"},{"key":"e_1_2_12_20_1","unstructured":"C. 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