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To date, no etiological therapy for FD is available, and the current management includes general measures, acid\u2010suppressive drugs, prokinetic agents, fundus\u2010relaxing drugs, antidepressants, and psychological interventions. Recent evidence suggests that microbiota imbalance is involved in the development of FD. As a consequence, the modulation of microbiota through the use of probiotics could represent an effective therapeutic strategy. Moreover, <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> (HP) infection is a frequent cause of dyspepsia, and patients diagnosed with HP\u2010associated dyspepsia are treated with <jats:italic>HP<\/jats:italic> eradication. In this regard, probiotics supplementation may also be helpful for HP infection to increase the eradication success rate as well as to reduce gastrointestinal adverse events caused by antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This review of the literature aims to summarize and discuss the current evidence on the use of probiotics in the treatment of dyspepsia and as a supplement to HP eradication therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70057","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T02:00:48Z","timestamp":1746669648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic Role of Probiotics for the Treatment of Dyspepsia: A Review of the 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