{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:14:29Z","timestamp":1791454469253,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mediterranean diet (MD) has been proposed as a dietary therapy for irritable bowel syndrome (IBS) but its efficacy remains unclear. We compared the efficacy of MD to a diet low in fermentable oligo\u2010, di\u2010, monosaccharides, and polyols (LFD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this pilot\u2010feasibility, randomized controlled trial (RCT), adult patients with diarrhea\u2010predominant IBS (IBS\u2010D) or mixed bowel pattern (IBS\u2010M) were randomized to MD versus LFD for 4\u2009weeks. Meals were provided for both groups (ModifyHealth, GA). Daily variables included abdominal pain intensity (API) and bloating, while IBS symptom severity score (IBS\u2010SSS) and IBS adequate relief (IBS\u2010AR) were scored weekly. The primary endpoint was the proportion of patients with \u2265\u200930% decrease in API for \u2265\u20092\/4\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 26 randomized patients, 20 finished the study (10 per group). Seventy\u2010three percent of the MD group met the primary endpoint compared to 81.8% of the LFD group (<jats:italic>p<\/jats:italic>\u2009=\u20091.0). Although not statistically significant, a numerically higher proportion of the LFD group reported adequate relief and met the responder endpoint for IBS\u2010SSS (50\u2010point reduction) compared to the MD group (54.6% vs. 27.3% for IBS\u2010AR and 81.8% vs. 45.5% for IBS\u2010SSS, <jats:italic>p<\/jats:italic>\u2009=\u20090.39 and 0.18, respectively). The LFD group also had a significantly greater reduction in IBS\u2010SSS score over the 4\u2010week treatment period compared to the MD group (\u2212105.5 vs. \u221260, <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MD provides symptom relief in IBS\u2010D and IBS\u2010M; however, the magnitude of relief was higher with the LFD. Larger diet comparison studies in real\u2010world settings are needed before MD can be routinely recommended to IBS patients.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>: NCT05807919.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70060","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T14:54:00Z","timestamp":1745506440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of Mediterranean Diet vs. Low\u2010<scp>FODMAP<\/scp> Diet in Patients With Nonconstipated Irritable Bowel Syndrome: A Pilot Randomized Controlled Trial"],"prefix":"10.1111","volume":"37","author":[{"given":"Prashant","family":"Singh","sequence":"first","affiliation":[{"name":"Divsion of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Dean","sequence":"additional","affiliation":[{"name":"Divsion of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Iram","sequence":"additional","affiliation":[{"name":"Divsion of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Westley","family":"Peng","sequence":"additional","affiliation":[{"name":"Divsion of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Chey","sequence":"additional","affiliation":[{"name":"Divsion of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara","family":"Rifkin","sequence":"additional","affiliation":[{"name":"Divsion of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lothen\u2010Kline","sequence":"additional","affiliation":[{"name":"Modify Health  Alpharetta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Muir","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Central Clinical School, Monash University and Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Divsion of Gastroenterology and Hepatology, Department of Internal Medicine Michigan Medicine  Ann Arbor 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