{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:17:34Z","timestamp":1782271054966,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015766","name":"Danone Nutricia Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015766","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The daily prevalence, impact, and associated personal and health factors of gas\u2010related gastrointestinal (GI) symptoms in the general population are poorly understood and were investigated in a multi\u2010national sample in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults (18+ years) were surveyed nationwide via the Internet in the United States (USA), the United Kingdom (UK), and Mexico. The survey included the Intestinal Gas Questionnaire (IGQ), Rome IV diagnostic questions, anxiety, depression, somatization, and Quality of Life (QoL) questionnaires, as well as healthcare use and medical history questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five thousand nine hundred and seventy\u2010eight respondents completed the survey: 49.1% female; mean age 44.8\u2009years. IGQ global scores (range 0\u2013100) were higher in Mexico (26.0) than in the United States (14.5) and the United Kingdom (13.7), higher among individuals under age 50 than older people, and only in Mexico higher in females than males. Almost all survey respondents (89%) reported one or more of the 7 IGQ gas\u2010related symptoms in the past 24\u2009h, with prevalence ranging from 39% for bloating to 81% for flatulence. Higher IGQ global scores correlated with lower physical (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.46) and mental (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.33) QoL; higher life stress (<jats:italic>r<\/jats:italic>\u2009=\u20090.43), anxiety (<jats:italic>r<\/jats:italic>\u2009=\u20090.43) and depression (<jats:italic>r<\/jats:italic>\u2009=\u20090.44) scores; and more non\u2010GI physical symptoms (<jats:italic>r<\/jats:italic>\u2009=\u20090.50). A greater gas\u2010related symptom burden was also related to higher prevalence of other gastroduodenal and bowel symptoms and increased doctor visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nearly all adults experience some daily gas\u2010related symptoms. A higher burden of these symptoms is robustly associated with impairment in general QoL, increased anxiety, depression, stress, other GI symptoms, and increased healthcare needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.70076","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:14:29Z","timestamp":1747725269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gas\u2010Related Symptoms in the General Population: Prevalence, Impact and Associated Factors in a Survey of the United States, the United Kingdom, and Mexico"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-3708","authenticated-orcid":false,"given":"Olafur S.","family":"Palsson","sequence":"first","affiliation":[{"name":"University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Drossman","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill and The Rome Foundation  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tack","family":"Jan","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Le Nev\u00e9","sequence":"additional","affiliation":[{"name":"Danone Global Research &amp; Innovation Center  Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Quinquis","sequence":"additional","affiliation":[{"name":"Danone Global Research &amp; Innovation Center  Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Hassouna","sequence":"additional","affiliation":[{"name":"Danone Global Research &amp; Innovation Center  Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannah","family":"Ruddy","sequence":"additional","affiliation":[{"name":"The Rome Foundation  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-8542","authenticated-orcid":false,"given":"Max J.","family":"Schmulson","sequence":"additional","affiliation":[{"name":"Laboratorio de H\u00edgado, P\u00e1ncreas y Motilidad (HIPAM), Unit of Research in Experimental Medicine, Faculty of Medicine Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn B.","family":"Morris","sequence":"additional","affiliation":[{"name":"The Rome Foundation  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant I.","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, and Population Health Research Institute McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005554103531"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.10.031"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.142810"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15167"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01303162"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01755.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.5.690"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.05.049"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00666.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.03.056"},{"key":"e_1_2_10_12_1","first-page":"561","article-title":"Management Strategies for Abdominal Bloating and Distension","volume":"10","author":"Foley A.","year":"2014","journal-title":"Gastroenterology and Hepatology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2006.00702.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105367"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13128"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002044"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14202"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12565"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522001593"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.014"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200203000-00008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(09)70864-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9496-9"},{"key":"e_1_2_10_24_1","first-page":"77","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14364"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14577"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282f53a24"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001858"}],"container-title":["Neurogastroenterology &amp; 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