{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:34:17Z","timestamp":1790969657742,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nausea can coexist in functional dyspepsia (FD) but the literature is poor in reporting whether this symptom is mainly triggered by meal ingestion. Moreover, the prevalence of nausea in FD is understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients with a disorder of gut\u2013brain interaction (DGBI) recruited in secondary and tertiary care facilities completed the enhanced Asian Rome IV questionnaire with additional questions to address the relationship between nausea and food intake. A comparison of nausea and the prevalence of meal\u2010related nausea was made among FD subgroups and with chronic nausea and vomiting syndrome (CNVS), both according to Rome IV criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Of the 1075 DGBI patients that completed the survey, 443 were classified as having FD and 44 other patients fulfilled diagnostic criteria for CNVS. The PDS\u2010EPS overlap group had a higher prevalence of nausea compared to PDS and EPS patients. In PDS patients with nausea, nausea was significantly more often meal\u2010related (than in PDS\u2010EPS overlap, EPS, and CNVS patients). All patients with meal\u2010related nausea reported that nausea started mostly (&gt;\u200985% of times) within 60\u2009min after the meal. When comparing western and eastern participating centers, nausea was more prevalent in patients from western sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Interferences<\/jats:title>\n                    <jats:p>Nausea is a highly prevalent symptom in FD with a higher prevalence in the PDS\u2013EPS overlap group. However, meal\u2010related nausea is more common in PDS. The pathophysiology of nausea in FD and its implication for medical treatment require further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.70078","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T15:33:33Z","timestamp":1748878413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the Prevalence of Meal\u2010Related Nausea in Different Functional Dyspepsia Subgroups"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-8461","authenticated-orcid":false,"given":"Bert","family":"Broeders","sequence":"first","affiliation":[{"name":"Department of Chronic Diseases, Metabolism and Aging (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven  Leuven Belgium"},{"name":"Department of Gastroenterology and Hepatology University Hospital of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Colomier","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases, Metabolism and Aging (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Simr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-8510","authenticated-orcid":false,"given":"Tao","family":"Bai","sequence":"additional","affiliation":[{"name":"Gastroenterology Department of Wuhan Union Tongji Medical College of Huazhong Science and Technology University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Liu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department of Wuhan Union Tongji Medical College of Huazhong Science and Technology University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Melchior","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Univ Rouen Normandie, INSERM, Normandie Univ, ADEN UMR1073, Nutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis, CHU Rouen, CIC\u2010CRB 1404  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9155","authenticated-orcid":false,"given":"Guillaume","family":"Gourcerol","sequence":"additional","affiliation":[{"name":"Department of Physiology Univ Rouen Normandie, INSERM, Normandie Univ, ADEN UMR1073, Nutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis, CHU Rouen, CIC\u2010CRB 1404  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-7546","authenticated-orcid":false,"given":"Kee\u2010Huat","family":"Chuah","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoo Xin","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-0590","authenticated-orcid":false,"given":"Sanjiv","family":"Mahadeva","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewin Tien Ho","family":"Siah","sequence":"additional","affiliation":[{"name":"Department of Medicine National University of Singapore and Gleneagles Hospital  Tanglin Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok\u2010Ann","family":"Gwee","sequence":"additional","affiliation":[{"name":"Department of Medicine National University of Singapore and Gleneagles Hospital  Tanglin Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lipt\u00e1k","sequence":"additional","affiliation":[{"name":"Clinic of Internal Medicine\u2010Gastroenterology University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University  Martin Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Banovcin","sequence":"additional","affiliation":[{"name":"Clinic of Internal Medicine\u2010Gastroenterology University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University  Martin Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-2358","authenticated-orcid":false,"given":"Gerald","family":"Holtmann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology of Princess Alexandra Hospital University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-5933","authenticated-orcid":false,"given":"Natasha","family":"Koloski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology of Princess Alexandra Hospital University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9984-4630","authenticated-orcid":false,"given":"Marilia","family":"Carabotti","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sapienza University, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-5957","authenticated-orcid":false,"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sapienza University, Sant'Andrea University Hospital  Rome 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